How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People

Circulation
Julie GeorgeHarry Hemingway

Abstract

Given the recent declines in heart attack and stroke incidence, it is unclear how women and men differ in first lifetime presentations of cardiovascular diseases (CVDs). We compared the incidence of 12 cardiac, cerebrovascular, and peripheral vascular diseases in women and men at different ages. We studied 1 937 360 people, aged ≥ 30 years and free from diagnosed CVD at baseline (51% women), using linked electronic health records covering primary care, hospital admissions, acute coronary syndrome registry, and mortality (Cardiovascular Research Using LInked Bespoke Studies and Electronic Records [CALIBER] research platform). During 6 years median follow-up between 1997 and 2010, 114 859 people experienced an incident cardiovascular diagnosis, the majority (66%) of which were neither myocardial infarction nor ischemic stroke. Associations of male sex with initial diagnoses of CVD, however, varied from strong (age-adjusted hazard ratios, 3.6-5.0) for abdominal aortic aneurysm, myocardial infarction, and unheralded coronary death (particularly >60 years), through modest (hazard ratio, 1.5-2.0) for stable angina, ischemic stroke, peripheral arterial disease, heart failure, and cardiac arrest, to weak (hazard ratio <1.5) for transie...Continue Reading

References

May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Nov 15, 2003·Lancet·Fiona Turnbull, UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Oct 7, 2005·American Journal of Epidemiology·Robert J Glynn, Bernard Rosner
Dec 8, 2007·Lancet·Robert BeagleholeUNKNOWN Chronic Disease Action Group
Mar 13, 2008·European Heart Journal·Sonia S AnandUNKNOWN INTERHEART Investigators
Jul 25, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Florence Canoui-PoitrineUNKNOWN PRIME Study Group
Jan 19, 2010·British Journal of Clinical Pharmacology·Emily HerrettAndrew J Hall
Jun 12, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·Marjukka HyvärinenCoen D A Stehouwer
Jul 22, 2010·The New England Journal of Medicine·David Blumenthal, Marilyn Tavenner
Nov 26, 2010·JAMA : the Journal of the American Medical Association·J Michael Gaziano
Jul 29, 2011·Journal of Public Health·E M BurnsO D Faiz
Jan 19, 2012·Circulation. Heart Failure·Keith D Aaronson, Jennifer Cowger
Mar 14, 2012·American Journal of Epidemiology·Teri A ManolioFrancis S Collins
Apr 3, 2012·Lancet·Rory Collins
May 1, 2010·The Canadian Journal of Hospital Pharmacy·UNKNOWN Pharmacist Prescribing Task Force
Nov 3, 2012·JAMA : the Journal of the American Medical Association·Michael S Lauer
Dec 12, 2012·International Journal of Epidemiology·Spiros C DenaxasHarry Hemingway
Dec 15, 2012·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 11, 2013·Journal of Public Health·Rohini MathurLiam Smeeth
Nov 19, 2014·BMJ : British Medical Journal·Maarten J G LeeningJolien W Roos-Hesselink
Dec 4, 2014·The Lancet. Diabetes & Endocrinology·Anoop Dinesh ShahHarry Hemingway

❮ Previous
Next ❯

Citations

Jan 13, 2016·Current Atherosclerosis Reports·Michael D MiedemaSalim S Virani
Mar 12, 2016·Medicina clínica·Manuel Martínez-SellésMaría Teresa Vidán
Apr 9, 2016·JACC. Cardiovascular Imaging·Monica B PatelK Lance Gould
Apr 14, 2016·Semergen·M Martínez-SellésM T Vidán
Apr 23, 2016·Revista española de geriatría y gerontología·Manuel Martínez-SellésMaría Teresa Vidán
Jul 28, 2016·Journal of Cardiovascular Computed Tomography·Anne-Lise HachullaJean-Paul Vallée
Sep 8, 2016·The Lancet. Diabetes & Endocrinology· Natriuretic Peptides Studies CollaborationEmanuele Di Angelantonio
Oct 16, 2016·The American Journal of Cardiology·Olga Perelshtein BrezinovRobert Klempfner
Nov 9, 2016·Annales de cardiologie et d'angéiologie·S Manzo-Silberman
Jul 22, 2017·Nature Reviews. Neurology·Charlotte CordonnierUNKNOWN Women Initiative for Stroke in Europe (WISE) group
Mar 15, 2018·Journal of Cardiovascular Medicine·Paolo Gresele
Jan 26, 2018·European Heart Journal·Harry HemingwayUNKNOWN Innovative Medicines Initiative 2nd programme, Big Data for Better Outcomes, BigData@Heart Consortium of 20 academic and ind
Mar 9, 2018·European Journal of Preventive Cardiology·Yochai SchonmannHanny Yeshua
Apr 7, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Samarth S PatelMohammad S Siddiqui
Apr 28, 2018·Circulation Research·Kalliopi TrachanaLeroy E Hood
Jun 23, 2016·Journal of the American Heart Association·Pauliina KangasIlkka Pörsti
Oct 24, 2018·European Heart Journal·Stephan Achenbach
Mar 7, 2019·Journal of Women's Health·Alison M WhiteheadSally G Haskell
Jul 23, 2019·Journal of the American Medical Informatics Association : JAMIA·Spiros DenaxasHarry Hemingway
Aug 14, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Amitava BanerjeeHarry Hemingway
Oct 31, 2019·Journal of the American Heart Association·Ethan J RowinBarry J Maron
Nov 2, 2019·Journal of Atherosclerosis and Thrombosis·Michio Shimabukuro
Apr 21, 2020·Journal of the American Heart Association·Michiel H F PoorthuisSarah Lewington
Nov 9, 2017·The British Journal of Surgery·S T W van HaelstG J de Borst
Apr 1, 2016·European Heart Journal. Quality of Care & Clinical Outcomes·Julie George
Aug 16, 2018·Current Hypertension Reports·Manav NayyarCamila Manrique Acevedo
Apr 1, 2016·European Heart Journal. Quality of Care & Clinical Outcomes·Raffaele Bugiardini, Edina Cenko
Sep 29, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Anouk BokslagChristianne J M de Groot
Aug 28, 2020·Clinical Science·Paul J ConnellyChristian Delles

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Methods Mentioned

BETA
hormone replacement therapy

Clinical Trials Mentioned

NCT01164371

Software Mentioned

Cardiovascular Research Using
LInked Bespoke Studies and Electronic Records ( CALIBER )

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