PMID: 8583092Sep 1, 1995Paper

How does chili cause upper gastrointestinal symptoms? A correlation study with esophageal mucosal sensitivity and esophageal motility

Journal of Clinical Gastroenterology
K G YeohJ Y Kang

Abstract

Chili ingestion produces gastrointestinal symptoms in many subjects. Some of these symptoms, such as heartburn, might well arise from the esophagus, but the pathogenesis is unknown. We studied the effects of chili ingestion on esophageal motility in 16 healthy volunteers and correlated these with the production of chili-induced upper gastrointestinal symptoms. We also studied the effects of chili instillation into the esophagus in 15 of the subjects to determine whether typical symptoms were produced. There were no changes in esophageal manometric parameters in all 16 subjects after the ingestion of a chili suspension (5 g chili powder in 100 ml water), although half of them reported one or more symptoms. Direct instillation of the same chili suspension into the lower esophagus produced typical symptoms in all 15 volunteers tested. Chili-induced upper gastrointestinal symptoms were not accompanied by changes in esophageal motility. The esophageal mucosa itself was sensitive to chili, suggesting that at least some of the upper gastrointestinal symptoms produced by chili are mediated by direct stimulation of chili-sensitive afferent nerve endings in the esophageal mucosa.

Citations

Apr 2, 2011·Journal of Gastroenterology and Hepatology·Khean-Lee Goh
Aug 4, 2010·Journal of Neurogastroenterology and Motility·Insuk So
Feb 25, 2010·The American Journal of Gastroenterology·Sanjiv MahadevaKhean-Lee Goh
Jul 14, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C L ChenW C Orr
Aug 16, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T T LiuC L Chen
Dec 27, 2016·World Journal of Gastroenterology : WJG·Chih-Hsun YiFabio Pace
Jan 10, 2003·Journal of Gastroenterology and Hepatology·Hideki IshikawaMasaki Kitajima
Sep 4, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Mahadeva, A C Ford
Nov 5, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jerome R LechienSven Saussez
Jul 8, 2011·Digestive Diseases and Sciences·Lee Guan LimKhek Yu Ho
Sep 14, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jerome R LechienSven Saussez

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