How does DNA 'meet' capillary-based microsystems?

The Analyst
Tingting HongPengju Jiang

Abstract

DNA possesses various chemical and physical properties which make it important in biological analysis. The opportunity for DNA to 'meet' capillary-based microsystems is rapidly increasing owing to the expanding development of miniaturization. Novel capillary-based methods can provide favourable platforms for DNA-ligand interaction assay, DNA translocation study, DNA separation, DNA aptamer selection, DNA amplification assay, and DNA digestion. Meanwhile, DNA exhibits great potential in the fabrication of new capillary-based biosensors and enzymatic bioreactors. Moreover, DNA has received significant research interest in improving capillary electrophoresis (CE) performance. We focus on highlighting the advantages of combining DNA and capillary-based microsystems. The general trend presented in this review suggests that the 'meeting' has offered a stepping stone for the application of DNA and capillary-based microsystems in the field of analytical chemistry.

References

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Citations

Nov 24, 2021·Analytical Chemistry·Tingting HongZhiqiang Cai

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Methods Mentioned

BETA
DNA assay
exponential enrichment
CE-SELEX
biosensors
electrophoresis
dynamic light scattering
optical tweezers
transmission electron microscopy
SELEX
PCR

Software Mentioned

icLAMP
cLAMP
ACE
ddRPA

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