How does four-dimensional computed tomography spare normal tissues in non-small cell lung cancer radiotherapy by defining internal target volume?

Thoracic Cancer
Tong BaiBo Yang

Abstract

To investigate how the four-dimensional computed tomography (4DCT) technique spares normal tissues in non-small cell lung cancer (NSCLC) radiotherapy by defining individualized internal target volume (ITV). Gross tumor volume (GTV) and clinical target volume (CTV) were contoured on all 10 respiratory phases of 4DCT scans in 10 patients with peripheral NSCLC. Both 3D and 4D treatment plans were performed for each patient using planning target volume (PTV)3D (derived from a single CTV plus conventional margins) and PTV4D (derived from 4D internal target volume, which included all 10 CTVs plus setup margins). Dose volume histogram and normal tissue complication probability (NTCP) values were compared for the lung, heart, and spinal cord between 3D and 4D treatment plans. The average PTV of the 4D (127.56 ± 70.79) was less than the 3D plans (147.65 ± 76.89). The 4D spared more surrounding normal tissues than the 3D plans, especially in the lung. Compared with 3D plans, V5, V10, V20 and V30 of the total lung decreased from 41.25%, 37.75%, 24.25%, 17.00% to 38.13%, 33.00%, 21.25%, 15.13%, respectively. Without increasing the NTCP of the lung significantly, the 4D plans allowed us to increase the average prescription dose from 60 Gy t...Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·C BurmanM Goitein
Aug 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J M BalterJ M Robertson
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·S ShimizuK Miyasaka
Feb 8, 2003·The Lancet Oncology·Geoff DelaneyBin Jalaludin
Jan 31, 2004·Seminars in Radiation Oncology·Paul Keall
Dec 18, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sarah BurdettUNKNOWN PORT Meta-analysis Group
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Eike RietzelChristopher G Willet
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·René W M UnderbergSuresh Senan
May 18, 2005·Medical Physics·Paul J KeallRadhe Mohan
May 16, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ylanga G van der GeldFrank J Lagerwaard
Aug 15, 2006·International Journal of Radiation Oncology, Biology, Physics·Eike RietzelNoah C Choi
Dec 26, 2006·International Journal of Radiation Oncology, Biology, Physics·Elisabeth WeissPaul J Keall
Aug 31, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mian XiNian-Ji Cui
Oct 22, 2008·International Journal of Radiation Oncology, Biology, Physics·Li WangFeng-Ming Kong
Nov 12, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jian ZhuRenaud De Crevoisier
May 10, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Feng Xiang LiChang Sheng Ma
May 14, 2011·Lancet·Peter GoldstrawFrances A Shepherd
Jan 12, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·N Hodapp

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Citations

Mar 1, 2019·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Fawzi AbuhijlaJamal Khader
Nov 25, 2021·Journal of Applied Clinical Medical Physics·Rhydian CainesCarl G Rowbottom

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