How does motion affect GABA-measurements? Order statistic filtering compared to conventional analysis of MEGA-PRESS MRS

PloS One
Sofie TapperPeter Lundberg

Abstract

The aim of this study was to evaluate two post-processing techniques applied to MRS MEGA-PRESS data influenced by motion-induced artifacts. In contrast to the conventional averaging technique, order statistic filtering (OSF) is a known method for artifact reduction. Therefore, this method may be suitable to incorporate in the GABA quantification. Twelve healthy volunteers were scanned three times using a 3 T MR system. One measurement protocol consisted of two MEGA-PRESS measurements, one reference measurement and one measurement including head motions. The resulting datasets were analyzed with the standard averaging technique and with the OSF-technique in two schemes; filtering phase cycles 'RAW PC' and filtering dynamics 'RAW Dyn'. The datasets containing artifacts resulted in an underestimation of the concentrations. There was a trend for the OSF-technique to compensate for this reduction when quantifying SNR-intense signals. However, there was no indication that OSF improved the estimated GABA concentrations. Moreover, when only considering the reference measurements, the OSF technique was equally as effective as averaging, which suggests that the techniques are interchangeable. OSF performed equally well as the conventiona...Continue Reading

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Citations

Nov 13, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sofie TapperPeter Lundberg

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Methods Mentioned

BETA
Magnetic

Software Mentioned

Reconframe
PRESS
TARQUIN
GyroTools
SDAT
COORD
jMRUI
MEGA
LCModel

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