How does P-glycoprotein recognize its substrates?

Seminars in Cancer Biology
K UedaM Morishima

Abstract

We review how P-glycoprotein recognizes a wide variety of compounds and how it carries its substrates across membranes. Amino acid substitutions that affect the substrate specificity of P-glycoprotein have been found scattered throughout the molecule. In particular, some amino acid residues in the putative transmembrane domain (TM) 1 together with TM5-6 and TM11-12 may help to govern substrate specificity. The features that substrates for P-glycoprotein share are also discussed. The amphipathy of a substrate may decide whether the substrate can be intercalated into the lipid bilayer of the membrane. In addition, only certain molecular volumes and tertiary structures may make it possible for the substrate to fit into the substrate-binding site(s) of P-glycoprotein.

Citations

Dec 16, 2000·The EMBO Journal·C MoreauM Vivaudou
Dec 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·M PutmanW N Konings
Jun 5, 2002·Annual Review of Biochemistry·P Borst, R Oude Elferink
Jan 31, 2006·FEBS Letters·Annie Frelet, Markus Klein
Apr 10, 2004·Drug Metabolism Reviews·Shufeng ZhouBalram Chowbay
Dec 15, 2010·Expert Opinion on Biological Therapy·Massimo Breccia, Francesco Lo-Coco
Dec 2, 2014·Pharmacology & Therapeutics·Renata SilvaFernando Remião
Jun 12, 2012·Biomaterials·Jinhua LiuYongzhuo Huang
Dec 27, 2011·Advanced Drug Delivery Reviews·Chunbo ZhangLarry Baum
Mar 27, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·K YamadaM-A Hattori
Jul 27, 2005·British Journal of Clinical Pharmacology·Balram ChowbayEdmund J D Lee
Feb 27, 2004·Biochemical and Biophysical Research Communications·Henrietta NagyGábor Szabó
Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Frouzandeh Mahjoubi, Soodeh Akbari
Mar 21, 2002·The Journal of Pharmacy and Pharmacology·Toshiyuki SakaedaKatsuhiko Okumura
Dec 6, 2014·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·LeeRon Shefet-Carasso, Itai Benhar
Jun 14, 2016·Acta Pharmacologica Sinica·Zhen-Zhen PanYong-Zhuo Huang
Oct 13, 2016·Biochemical Pharmacology·Rituparna MittraRichard Callaghan
May 29, 2004·FEBS Letters·Balázs SarkadiAndrás Váradi
Jul 6, 2014·Journal of the American Chemical Society·Ting-Fang KuoMotonari Uesugi
Apr 8, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Anette WeyergangKristian Berg
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saikat DewanjeeMuhammad Zia-Ul-Haq
Jan 11, 2018·Journal of Cellular Physiology·Hadi NasiriJafar Majidi
Feb 21, 2004·Human Molecular Genetics·Kun TangCaroline G L Lee
Dec 8, 2004·FEBS Letters·Frédéric BuyseJean-Marie Ruysschaert
Dec 20, 2002·Clinical Pharmacokinetics·Jiunn H Lin, Masayo Yamazaki
Mar 4, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y RavivR Blumenthal
Mar 2, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Vikram AryaGünther Hochhaus
May 25, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Philip H ElsingaWillem Vaalburg
Mar 23, 2011·Drug Metabolism and Drug Interactions·Yamsani Shravan KumarYamsani Madhusudan Rao
Sep 26, 2019·Chemico-biological Interactions·Clarissa Feltrin, Cláudia Maria Oliveira Simões

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