How does pain induce negative emotion? Role of the bed nucleus of the stria terminalis in pain-induced place aversion

Current Molecular Medicine
Masabumi Minami, Soichiro Ide

Abstract

Pain consists of sensory-discriminative and negative-affective components. Neuronal mechanisms for the sensory component of pain have been investigated extensively. On the other hand, neuronal mechanisms for the affective component of pain remain to be investigated. Recent behavioral studies have revealed the brain regions and neuronal mechanisms involved in the affective component of pain. Glutamatergic transmission within the anterior cingulate cortex and basolateral amygdaloid nucleus plays a critical role in pain-induced aversion. Noradrenaline and corticotropin-releasing factor (CRF) within the ventral and dorsolateral parts of the bed nucleus of the stria terminalis (BNST), respectively, play important roles in paininduced aversion. Electrophysiological studies have revealed that both noradrenaline and CRF activate type II BNST neurons, which may inhibit the BNST output neurons. A recent histochemical study showed that most VTA-projecting BNST output neurons are GABAergic neurons, which preferentially make synaptic contact with VTA GABAergic neurons. Therefore, activation of VTA-projecting BNST output neurons should increase the neuronal excitability of VTA dopaminergic (DAergic) neurons through increased inhibitory input...Continue Reading

Citations

Jan 23, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chia LiThomas L Kash
Aug 18, 2017·Learning & Memory·Travis D Goode, Stephen Maren
May 30, 2020·Neuropharmacology·Elizabeth C Delery, Scott Edwards

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