How does pain lead to disability? A systematic review and meta-analysis of mediation studies in people with back and neck pain

Pain
Hopin LeeJames H McAuley

Abstract

Disability is an important outcome from a clinical and public health perspective. However, it is unclear how disability develops in people with low back pain or neck pain. More specifically, the mechanisms by which pain leads to disability are not well understood. Mediation analysis is a way of investigating these mechanisms by examining the extent to which an intermediate variable explains the effect of an exposure on an outcome. This systematic review and meta-analysis aimed to identify and examine the extent to which putative mediators explain the effect of pain on disability in people with low back pain or neck pain. Five electronic databases were searched. We found 12 studies (N = 2961) that examined how pain leads to disability with mediation analysis. Standardized regression coefficients (β) of the indirect and total paths were pooled. We found evidence to show that self-efficacy (β = 0.23, 95% confidence interval [CI] = 0.10 to 0.34), psychological distress (β = 0.10, 95% CI = 0.01 to 0.18), and fear (β = 0.08, 95% CI = 0.01 to 0.14) mediated the relationship between pain and disability, but catastrophizing did not (β = 0.07, 95% CI = -0.06 to 0.19). The methodological quality of these studies was low, and we highlight ...Continue Reading

References

Oct 1, 1992·Baillière's Clinical Rheumatology·G Waddell
Jan 1, 1983·Behaviour Research and Therapy·J LethemG Bentley
May 26, 1999·Pain·J A BorghoutsL M Bouter
Nov 24, 1999·Scandinavian Journal of Work, Environment & Health·W E HoogendoornL M Bouter
Apr 1, 2000·Scandinavian Journal of Work, Environment & Health·G A AriënsG van der Wal
May 4, 2002·Best Practice & Research. Clinical Rheumatology·Andreas Maetzel, Linda Li
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 17, 2003·Journal of Abnormal Psychology·David A Cole, Scott E Maxwell
Nov 25, 2004·Pain·Judith A TurnerThomas M Wickizer
Jan 12, 2005·The Journal of Applied Psychology·Robert A Peterson, Steven P Brown
Feb 1, 2006·European Journal of Pain : EJP·Michael K Nicholas
Mar 21, 2006·European Journal of Pain : EJP·Maaike LeeuwJohan W S Vlaeyen
Sep 14, 2006·Annual Review of Psychology·David P MacKinnonMatthew S Fritz
Apr 4, 2007·Psychological Methods·Scott E Maxwell, David A Cole
Apr 21, 2007·Psychological Science·Matthew S Fritz, David P Mackinnon
Jun 27, 2007·Psychological Bulletin·Robert J GatchelDennis C Turk
Jan 1, 2008·The Spine Journal : Official Journal of the North American Spine Society·Simon DagenaisScott Haldeman
Jul 22, 2008·European Journal of Pain : EJP·Rubén NietoAnna Huguet
May 30, 2009·Pain·Timothy H WidemanMichael J L Sullivan
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Sep 1, 2009·Journal of Nutrition Education and Behavior·Ester CerinTom Baranowski
Mar 2, 2010·European Journal of Pain : EJP·Els L M GheldofJohan W S Vlaeyen
May 28, 2010·Personality and Social Psychology Review : an Official Journal of the Society for Personality and Social Psychology, Inc·David M Williams
Sep 16, 2010·The Clinical Journal of Pain·Tamar PincusMichael J L Sullivan
Oct 20, 2010·Psychological Methods·Kosuke ImaiDustin Tingley
Feb 11, 2011·Pain·Amanda M HallMichael K Nicholas
Mar 19, 2011·Western Journal of Nursing Research·Jennifer LeemanMargarete Sandelowski
Apr 1, 2011·Physical Therapy·Jonathan C Hill, Julie M Fritz
Apr 14, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M M van StralenUNKNOWN ENERGY-consortium

❮ Previous
Next ❯

Citations

Jun 15, 2015·The Journal of Pain : Official Journal of the American Pain Society·Cassie RossJames H McAuley
Jul 5, 2016·Clinical Reviews in Bone and Mineral Metabolism·Kozo Nakamura, Toru Ogata
Sep 1, 2016·The Journal of Pain : Official Journal of the American Pain Society·Hopin LeeJames H McAuley
Sep 3, 2016·The Journal of Pain : Official Journal of the American Pain Society·Robert R EdwardsAjay D Wasan
Mar 28, 2017·Disability and Rehabilitation·Hillevi BuschIrene Jensen
Dec 28, 2017·European Journal of Pain : EJP·N M BlackR Mani
Aug 31, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Trevor A LentzSteven Z George
Aug 1, 2019·Physical & Occupational Therapy in Pediatrics·Rosa Andias, Anabela G Silva
Jan 25, 2020·Scandinavian Journal of Pain·Leif MåweGunnvald Kvarstein
Jun 23, 2020·Journal of Clinical Psychology·Jillian SucherAdam D Brown
Sep 11, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jacob DaheimNguyen P Nguyen
Sep 3, 2018·International Archives of Occupational and Environmental Health·Matthew L StevensCharlotte D N Rasmussen
Sep 28, 2018·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Shannon Ang, Tuo-Yu Chen
May 7, 2020·International Journal of Occupational Safety and Ergonomics : JOSE·Bilge Basakci CalikDerya Caglar
Apr 14, 2020·Journal of Pain Research·Anne-Katrin PuschmannPia-Maria Wippert
Aug 21, 2020·The Clinical Journal of Pain·Kasper S ChristensenThorvaldur S Palsson
Apr 9, 2015·Pain·Stephen Morley, Amanda C de C Williams
May 23, 2020·Pain Reports·Steven Z GeorgeJeff Boissoneault

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.