How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder

Brain : a Journal of Neurology
R B PostumaJ Y Montplaisir

Abstract

Parkinsonism, as a gradually progressive disorder, has a prodromal interval during which neurodegeneration has begun but cardinal manifestations have not fully developed. A systematic direct assessment of this interval has never been performed. Since patients with idiopathic REM sleep behaviour disorder are at very high risk of parkinsonism, they provide a unique opportunity to observe directly the development of parkinsonism. Patients with idiopathic REM sleep behaviour disorder in an ongoing cohort study were evaluated annually with several quantitative motor measures, including the Unified Parkinson's Disease Rating Scale, Purdue Pegboard, alternate-tap test and timed up-and-go. Patients who developed parkinsonism were identified from this cohort and matched according to age to normal controls. Their results on motor testing from the preceding years were plotted, and then assessed with regression analysis, to determine when markers first deviated from normal values. Sensitivity and specificity of quantitative motor markers for diagnosing prodromal parkinsonism were assessed. Of 78 patients, 20 developed parkinsonism. On regression analysis, the Unified Parkinson's Disease Rating Scale first intersected normal values at an es...Continue Reading

Associated Clinical Trials

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Jul 1, 1995·Disability and Rehabilitation·J DesrosiersE Dutil
Feb 4, 1998·Brain : a Journal of Neurology·J R Moeller, D Eidelberg
Apr 4, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·P K MorrishD J Brooks
Jun 1, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·E B MontgomeryK Lyons
Jun 1, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·E B MontgomeryW C Koller
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·J G NuttG J Sexton
Mar 21, 2007·Neurology·Anthony E Lang
Dec 22, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Bruno DuboisMurat Emre
Nov 19, 2008·Parkinsonism & Related Disorders·A Jon Stoessl
Apr 26, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N I BohnenR Y Moore
Oct 1, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer G GoldmanGlenn T Stebbins
Aug 12, 2009·Annals of Neurology·Jean-François GagnonJacques Montplaisir
Sep 22, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaJacques Y Montplaisir
Feb 4, 2010·Parkinsonism & Related Disorders·Werner Poewe, Philipp Mahlknecht
Jun 22, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·R B PostumaJ Montplaisir
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Charlotte A HaaxmaMartin W I M Horstink
Sep 8, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Jacques MontplaisirJean Paquet
Jan 20, 2011·Annals of Neurology·Raúl de la Fuente-FernándezA Jon Stoessl
May 1, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·Erwin B MontgomeryKelly Lyons

❮ Previous
Next ❯

Citations

Jan 23, 2013·Journal of Neural Transmission·Martina KrenzerWolfgang Oertel
May 30, 2013·Journal of Neural Transmission·Philipp Mahlknecht, Werner Poewe
Jul 6, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Alastair J NoyceAnette Schrag
Nov 2, 2012·Neurology·Thien Thanh Dang-VuJacques Montplaisir
Aug 13, 2013·Environmental Health Perspectives·Honglei ChenJing Zhang
Apr 18, 2014·Nature Reviews. Neuroscience·Albert Costa, Núria Sebastián-Gallés
Aug 24, 2013·The Journal of the Acoustical Society of America·Jan RuszEvzen Ruzicka
Oct 16, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Kelly Del Tredici, Heiko Braak
Mar 29, 2014·Trends in Neurosciences·John PeeverJacques Montplaisir
Jul 1, 2014·Current Opinion in Neurology·Jennifer G Goldman, Ron Postuma
Jun 8, 2014·The Cerebellum·Luis Velázquez-PérezYanetza González-Zaldivar
Feb 7, 2014·Journal of Neural Transmission·Elizabeth J SlowAnthony E Lang
Dec 9, 2014·Alzheimer's Research & Therapy·Paul C Donaghy, Ian G McKeith
Mar 15, 2016·Sleep Medicine Clinics·Alex Iranzo
Sep 30, 2015·Expert Review of Neurotherapeutics·Naomi Visanji, Connie Marras
Nov 23, 2013·Parkinsonism & Related Disorders·Ronald B Postuma
Oct 8, 2013·Journal of Voice : Official Journal of the Voice Foundation·Tereza TykalovaEvzen Ruzicka
Feb 24, 2016·European Journal of Epidemiology·Sirwan K L DarweeshM Arfan Ikram
Feb 5, 2013·Sleep Medicine·Poul JennumRon Postuma
Dec 22, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Alberto BergarecheJosé Félix Martí-Massó
Oct 21, 2015·Journal of Parkinson's Disease·Philipp MahlknechtWerner Poewe
Nov 8, 2015·Neurobiology of Aging·Jessica Rodrigues BrazèteJacques Montplaisir
Jul 28, 2016·Sleep Medicine·Ronald B PostumaJacques Montplaisir
Apr 5, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaJacques Montplaisir
Oct 17, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Eric M McDadeRonald C Petersen
Jul 6, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Honglei ChenShyamal Peddada
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Nov 6, 2013·Journal of Neurology·Stefanie LercheDaniela Berg
Feb 19, 2015·Geriatrics & Gerontology International·Hiroshige FujishiroEizo Iseki
Mar 20, 2016·Lancet Neurology·David SalatEduardo Tolosa
Apr 15, 2016·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Bruno EllaDominique Guehl
Jun 16, 2015·Frontiers in Neurology·Jimmy J FraigneJohn H Peever
Jun 2, 2015·Alzheimer's Research & Therapy·Brendon P Boot
Dec 18, 2013·Parkinsonism & Related Disorders·Ryuji SakakibaraTsutomu Inaoka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.