PMID: 11916106Mar 28, 2002Paper

How does sibutramine work?

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
M E Lean

Abstract

Sibutramine offers three types of benefit in weight management: by enhancing weight loss, by improving weight maintenance and by reducing the comorbidities of obesity. The clinical effects of sibutramine are explained through its known mode of action as a serotonin (5-HT) and noradrenaline reuptake inhibitor (SNRI). This dual mechanism of action results in two synergistic physiological effects--a reduction in energy intake and an increase in energy expenditure, which combine to promote and maintain weight loss.

Citations

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