How does SIRT1 affect metabolism, senescence and cancer?

Nature Reviews. Cancer
Christopher L Brooks, Wei Gu

Abstract

SIRT1 is a multifaceted, NAD(+)-dependent protein deacetylase that is involved in a wide variety of cellular processes from cancer to ageing. The function of SIRT1 in cancer is complex: SIRT1 has been shown to have oncogenic properties by downregulating p53 activity, but recent studies indicate that SIRT1 acts as a tumour suppressor in a mutated p53 background, raising intriguing questions regarding its mechanism of action. Here we discuss the current understanding of how SIRT1 functions in light of recent discoveries and propose that the net outcome of the seemingly opposite oncogenic and tumour-suppressive effects of SIRT1 depends on the status of p53.

References

Feb 19, 2002·Oncogene·Titia de Lange
May 15, 2002·The EMBO Journal·Emma LangleyTony Kouzarides
May 25, 2002·Experimental Cell Research·Silvia Espejel, María A Blasco
Aug 30, 2002·The International Journal of Biochemistry & Cell Biology·Ana Krtolica, Judith Campisi
Oct 22, 2002·Nature Cell Biology·Zaher NahleScott W Lowe
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hwei-Ling ChengKatrin F Chua
Oct 3, 2003·The Journal of Biological Chemistry·Michael D JacksonJohn M Denu
Jan 1, 2004·The Journal of Clinical Investigation·Ittai Ben-Porath, Robert A Weinberg
Feb 26, 2004·Cell·Maria Carla MottaLeonard Guarente
Jun 4, 2004·Nature·Frédéric PicardLeonard Guarente
Mar 1, 2005·Cell·David B LombardFrederick W Alt
Mar 16, 2005·Nature Reviews. Molecular Cell Biology·Laura Bordone, Leonard Guarente
Jul 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kurt A KrummelGeoffrey M Wahl
Aug 2, 2005·Cell Metabolism·Katrin F ChuaFrederick W Alt
Aug 6, 2005·Science·Judith Campisi
Feb 4, 2006·Molecular Cell·Christopher L Brooks, Wei Gu
Mar 21, 2006·Mechanisms of Ageing and Development·Chang-Su LimRichard F Helm
Jul 29, 2006·Cancer Detection and Prevention·Simone Fulda, Klaus-Michael Debatin
Aug 8, 2006·Nature Cell Biology·Chuangui WangJiandong Chen
Nov 14, 2006·Journal of Biomolecular Screening·Vasantha M NayagamWalter Stünkel
Dec 21, 2006·Archives of Dermatological Research·Yasutoshi HidaSeiji Arase
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Qinghong ZhangRichard H Goodman
Feb 20, 2007·The Journal of Biological Chemistry·Eric van der VeerJ Geoffrey Pickering
Feb 24, 2007·Molecular Cell·Kotb AbdelmohsenMyriam Gorospe
Apr 17, 2007·Cell Biology International·Chang-Su Lim
Jul 7, 2007·Molecular Cell·Zhigang YuanEdward Seto
Jul 20, 2007·Cancer Research·Derek M HuffmanTim R Nagy

❮ Previous
Next ❯

Citations

May 23, 2009·Cell Death and Differentiation·H Hermeking
Apr 21, 2010·Cell Research·Christopher L Brooks, Wei Gu
Jul 25, 2009·Nature Reviews. Cancer·David B Shackelford, Reuben J Shaw
Nov 26, 2010·Nature Reviews. Cancer·Daniel Herranz, Manuel Serrano
Mar 7, 2012·Organic & Biomolecular Chemistry·Shridhar BhatJun O Liu
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mei MingYu-Ying He
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shoko KurodaYoshiko Iwai
Feb 20, 2010·The Journal of Biological Chemistry·Xiumei GuoXiaoling Li
Dec 15, 2010·The Journal of Biological Chemistry·Yasumichi InoueTakeshi Imamura
Mar 11, 2010·Antioxidants & Redox Signaling·Lisa G WoodManohar L Garg
Nov 20, 2010·Journal of the National Cancer Institute·Joong Sup ShimJun O Liu
May 12, 2010·Cold Spring Harbor Perspectives in Biology·David W Meek, Carl W Anderson
May 14, 2010·Cold Spring Harbor Perspectives in Biology·David P LaneSonia Lain
Sep 21, 2010·Biological Reviews of the Cambridge Philosophical Society·Amancio Carnero, Matilde E Lleonart
Aug 25, 2010·Molecular and Cellular Biology·Beum-Soo AnJohn H White
Nov 1, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yi WangXinfu Guan
Jul 20, 2012·Physiological Reviews·Ruben NogueirasMatthias H Tschöp
Sep 14, 2011·Journal of Biomedicine & Biotechnology·Ramkumar RajendranConstantinos Demonacos
Sep 17, 2011·Cancer Research·Selvakumar ElangovanMuthusamy Thangaraju
Mar 26, 2010·The Journal of Clinical Investigation·Wenjuan HeChuan-Ming Hao
Oct 4, 2013·BMC Cancer·Albrecht StenzingerWilko Weichert
Aug 31, 2012·Epigenetics & Chromatin·Kévin ContrepoisCarl Mann
Dec 17, 2009·Endocrine Reviews·Riekelt H HoutkooperJohan Auwerx
May 31, 2014·PLoS Genetics·Angela RelógioChristine Sers
Oct 15, 2010·Yi chuan = Hereditas·Wen-Jia YangWei-Guo Zhu
Jan 13, 2010·World Journal of Gastroenterology : WJG·Mitsuyasu NakamuraSoichiro Miura
Dec 24, 2013·Genome Integrity·Augustin LunaKurt W Kohn
Jan 10, 2013·International Journal of Clinical Oncology·Yongguo ZhangKaichun Wu
Jun 27, 2014·Nature Communications·Akiko Satoh, Shin-ichiro Imai
Feb 27, 2014·Diabetologia·Rokhsana MortuzaSubrata Chakrabarti
Aug 8, 2014·Experimental and Molecular Pathology·Hamidreza MaroofAlfred King-Yin Lam
Jan 19, 2010·Annual Review of Pathology·Marcia C Haigis, David A Sinclair

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.