How does socio-economic position (SEP) get biologically embedded? A comparison of allostatic load and the epigenetic clock(s)

Psychoneuroendocrinology
Cathal McCroryRose Anne Kenny

Abstract

Individuals of lower socio-economic position (SEP) carry a heavier burden of disease and morbidity and live shorter lives on average compared with their more advantaged counterparts. This has sparked research interest in the processes and mechanisms via which social adversity gets biologically embedded. The present study directly compares the empirical worth of two candidate mechanisms: Allostatic Load (AL) and the Epigenetic Clock(s) for advancing our understanding of embodiment using a sub-sample of 490 individuals from the Irish Longitudinal Study (TILDA) who were explicitly selected for this purpose based on their inter-generational life course social class trajectory. A battery of 14 biomarkers representing the activity of 4 different physiological systems: Immunological, Cardiovascular, Metabolic, and Renal was used to construct the AL score. Biomarkers were dichotomised into high and low risk groups according to sex-specific quartiles of risk and summed to create a count ranging from 0-14. Three measures of epigenetic age acceleration were computed according to three sets of age-associated Cytosine-phosphate-Guanine (CpG) sites described by Horvath, Hannum and Levine. AL was strongly socially patterned across a number of...Continue Reading

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Citations

Oct 12, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cathal McCroryRose Anne Kenny
Jul 26, 2019·European Journal of Epidemiology·Paolo Vineis, Michelle Kelly-Irving
Jun 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Andrew Steptoe, Paola Zaninotto
Nov 20, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cathal McCroryRose Anne Kenny
Aug 17, 2020·Neuroscience and Biobehavioral Reviews·Natasha M WoodSarah Cohen-Woods
Jan 17, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eileen M CrimminsJessica Faul
Feb 22, 2021·Social Science & Medicine·Linnea EvansKristen Malecki
Apr 29, 2021·Journal of Epidemiology and Community Health·Anitha GeorgeJane Maddock
Apr 20, 2021·Current Epidemiology Reports·Sarah N ForresterRoland J Thorpe
Aug 18, 2020·Psychotherapy and Psychosomatics·Jenny GuidiGiovanni A Fava

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