How does the human RUNX3 gene induce apoptosis in gastric cancer? Latest data, reflections and reactions

Cancer Biology & Therapy
Paraskevi VogiatziAntonio Giordano

Abstract

RUNX3 is the oldest known gene in the RUNX family. Data have demonstrated its function to be thoroughly involved the neurogenesis of the dorsal root ganglia, T-cell differentiation and tumorigenesis of gastric epithelium. As a TGF-beta target, RUNX3 protein is believed to be involved in TGF-beta-mediated tumor suppressor pathway; however, little is known about its role in apoptosis. According to recent data reported by Yamamura et al., (J Biol Chem 2006; 281:5267-76), RUNX3 interacts with FoxO3a/FKHRL1 expressed in gastric cancer cells to activate Bim and induce apoptosis. The cooperation between RUNX3 and the PI3K/Akt signaling pathway component FoxO3a/FKHRL1 suggests the putative role of RUNX3 in the homoeostasis of gastric cells and in stomach cancer control. Here we discuss recent breakthroughs in our understanding of the mechanisms of RUNX3 in gastric malignancy and comment on possible future trends and perspectives.

Citations

Nov 1, 2006·Expert Review of Clinical Immunology·Stanford L Peng
May 22, 2010·Cancer Letters·William K K WuJoseph J Y Sung
Feb 24, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kin Wai LaiUNKNOWN Singapore Gastric Cancer Consortium
Dec 4, 2014·Journal of the Neurological Sciences·Uxia Saraiva-EsperónMichel Herranz
Jul 31, 2012·World Journal of Gastrointestinal Oncology·Siddavaram Nagini
Jan 24, 2007·Journal of Cellular Physiology·Paraskevi VogiatziAntonio Giordano
Jan 8, 2021·International Immunopharmacology·Shanshan XuFaming Pan

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