How does tobacco smoke influence the morphometry of the fetus and the umbilical cord?-Research on pregnant women with intrauterine growth restriction exposed to tobacco smoke

Reproductive Toxicology
E Milnerowicz-Nabzdyk, Anna Bizoń

Abstract

Proper structure of the umbilical cord is important for the fetal development. We evaluated effects of toxic factors from tobacco smoke on fetal and umbilical cord morphometry. 109 women in weeks 29-40 of pregnancy (31 smokers with intrauterine growth restriction (IUGR); 28 non-smoking women with IUGR; 50 healthy pregnancies) were included. In smokers with IUGR, cotinine, cadmium and lead concentrations were significantly higher than in controls (mean 55.23ng/l; 1.52ng/ml; 14.85ng/ml vs 1.07; 0.34; 9.42) and inverse correlation between lead concentration and uncoiled umbilical cord was significant (r=-0.80). In smokers with IUGR, area of Wharton's jelly was increased compared to nonsmokers and controls. Inverse correlations occurred between cotinine and cadmium concentration and fetal percentile in smokers (r=-0.87; r=-0.87) and non-smokers (r=-0.47; r=-0.78) with IUGR. Exposure to tobacco smoke measured by cotinine, cadmium and lead concentration has an impact on fetal growth and umbilical cord morphometry and correlates with intensity of IUGR.

References

Sep 1, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F GhezziV D'Addario
Mar 6, 2004·BMJ : British Medical Journal·Tim Coleman
Jun 29, 2004·The European Respiratory Journal·H S SekhonE R Spindel
Jan 25, 2005·Toxicology·Ana Maria RoncoMiguel N Llanos
Apr 20, 2006·Toxicology·Ana Maria RoncoMiguel N Llanos
Dec 13, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Patrizia LuppiJulie A DeLoia
Feb 7, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·F A TogniL M M Nardozza
Aug 2, 2007·American Journal of Public Health·Michael RabinoffCandice Park
Oct 26, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A CromiL Raio
Dec 31, 2010·Therapeutic Drug Monitoring·Stephanie J MarinGwendolyn A McMillin
Nov 9, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Graziano ClericiGian Carlo Di Renzo
Feb 2, 2013·Journal of Obstetrics and Gynaecology of India·Dakshayini Devaru, Meghna Thusoo
Mar 19, 2013·International Journal of Molecular Sciences·Branislav Ruttkay-NedeckyRene Kizek
Dec 3, 2014·Reproductive Toxicology·Ewa Milnerowicz-Nabzdyk, Anna Bizoń

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Citations

Dec 24, 2015·Respiratory Research·Marcello LanariUNKNOWN Study Group of Italian Society of Neonatology on Risk Factors for RSV Hospitalization
Oct 31, 2016·Environmental Toxicology and Pharmacology·Marta WrześniakHalina Milnerowicz
Sep 13, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D D Di MartinoA Farina
Mar 7, 2020·Frontiers in Bioengineering and Biotechnology·Harvey HoPeter Hunter

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