How early do airway inflammation and remodeling occur?

Allergology International : Official Journal of the Japanese Society of Allergology
Andrew Bush

Abstract

Eosinophilic airway inflammation and structural airway changes are present in school age asthmatics. When these changes occur, and their relationship, are controversial. Some structural airway changes, up-regulation of collagens 1 and 111, and increased distance between alveolar tethering points, may be antenatal, and independent of inflammation. We have established that there is no eosinophilic inflammation or reticular basement membrane thickening in wheezing infants median age one year; but by age three years, both are present. This accords with cohort studies, showing that children who become persistent wheezers have a drop in lung function in the pre-school years. Thereafter, lung function tracks into middle age, so the preschool years represent window during which an intervention might have long term benefit. Supportive are measurements in blood and bronchoalveolar lavage fluid, implicating the neutrophil as the key inflammatory cell in early wheeze. Models of the pathophysiology of asthma include (1) that eosinophilic inflammation is the primary event, and leads to remodelling as a secondary event, which itself results in progressive airflow obstruction (the least likely model); (2) eosinophilic inflammation is the prima...Continue Reading

References

Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·P J StoneG L Snider
Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
Jan 1, 1997·Pediatric Pulmonology·H OswaldA Olinsky
Aug 1, 1997·The European Respiratory Journal·K C Lødrup CarlsenK H Carlsen
Jul 25, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E C StevensonM D Shields
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·J ElliotP Robinson
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·C MarguetJ O Warner
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·J ElliotP Robinson
Feb 12, 2000·The Journal of Allergy and Clinical Immunology·S T HolgateJ L Lordan
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·U FreyM Silverman
Jul 8, 2000·The European Respiratory Journal·S ViglioM Luisetti
Oct 14, 2000·Archives of Disease in Childhood·A Bush
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·J ElliotP Robinson
Aug 18, 2001·Journal of Applied Physiology·M MilaneseV Brusasco
Dec 26, 2001·American Journal of Respiratory Cell and Molecular Biology·Harmanjatinder S SekhonEliot R Spindel
Feb 28, 2002·Respiratory Medicine·D FiorenzaG L Snider
Apr 12, 2002·The International Journal of Biochemistry & Cell Biology·Franca CocciGiuseppe Lungarella
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Frank D GillilandJohn M Peters
Sep 13, 2002·Chest·Muriel Le BourgeoisJacques de Blic
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Yasushi Fujitani, Alexandre Trifilieff
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·John G ElliotPhilip J Robinson
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Donald N R PaynePeter K Jeffery
Jan 18, 2003·American Journal of Respiratory and Critical Care Medicine·Laurent BenayounMarina Pretolani
Mar 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alexander AuaisGiovanni Piedimonte
May 27, 2003·Archives of Disease in Childhood·A OommenJ Grigg
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthias SchmidtSabrina Mattoli
Aug 2, 2003·American Journal of Respiratory and Critical Care Medicine·Angelo BarbatoMarina Saetta
Sep 23, 2003·Archives of Disease in Childhood·P S McNamaraR L Smyth
Oct 10, 2003·The New England Journal of Medicine·Malcolm R SearsRichie Poulton
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Jacques de BlicPhilippe Gosset
Feb 7, 2004·American Journal of Respiratory and Critical Care Medicine·Stephen W TurnerPeter N Le Souëf
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·Bruno MahutJacques de Blic
Aug 31, 2004·American Journal of Respiratory Cell and Molecular Biology·Simon PhippsA Barry Kay
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Nele SigursBengt Kjellman
Jan 20, 2005·American Journal of Respiratory and Critical Care Medicine·Sejal SaglaniPeter K Jeffery
Feb 8, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·P PohunekW R Roche
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sylvie NaveauThierry Poynard

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Citations

May 17, 2011·World Journal of Pediatrics : WJP·Wei-Xi Zhang, Chang-Chong Li
Oct 15, 2008·Annual Review of Physiology·Omar Tliba, Reynold A Panettieri
Apr 24, 2009·Proceedings of the American Thoracic Society·Fernando D Martinez
Sep 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Theresa W GuilbertAnne M Fitzpatrick
Jul 5, 2011·Paediatric Respiratory Reviews·Xiao Yan HeFang Wang
Sep 21, 2011·Drug Discovery Today·Paolo Montuschi, Peter J Barnes
Apr 19, 2011·The Journal of Allergy and Clinical Immunology·Rachel A CollinsPeter D Sly
Nov 26, 2010·Immunology and Allergy Clinics of North America·Rosalind J Wright
Jan 19, 2010·Biological Psychology·Rosalind J Wright
Feb 6, 2010·The Journal of Allergy and Clinical Immunology·Sylvia VerbanckWalter Vincken
Mar 3, 2009·Radiologic Clinics of North America·Alyn Q Woods, David A Lynch
Dec 17, 2008·Pediatric Pulmonology·Nicolas RegameyJane C Davies
Jun 25, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Surendran ThavagnanamMichael D Shields
May 27, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Michael J EvansDallas M Hyde
Nov 21, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M A G E BannierEdward Dompeling
Jun 30, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M H BoskabadyG Byrami
Sep 23, 2009·Mutation Research·Jenna R Murdoch, Clare M Lloyd
Feb 2, 2017·Journal of Clinical Laboratory Analysis·Nevenka Ilic, Natasa Mihailovic
Jan 14, 2017·American Journal of Respiratory and Critical Care Medicine·Y S PrakashUNKNOWN ATS Assembly on Respiratory Structure and Function
Jun 10, 2011·International Archives of Allergy and Immunology·Kenji MatsumotoHirohisa Saito
Mar 2, 2018·Pediatric Pulmonology·Stephane DebelleixMichael Fayon
Jul 6, 2014·Allergy, Asthma & Immunology Research·Ozge YilmazHasan Yuksel
Mar 25, 2009·Current Opinion in Allergy and Clinical Immunology·Karin C Lødrup CarlsenKai-Håkon Carlsen
Jan 10, 2020·Physiological Reviews·Anuradha RaySally E Wenzel
Jun 16, 2017·Physiology·Kenneth R LutchenChun Y Seow
Jul 14, 2010·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Isabela Furtado de Mendonça PicininChristophe Marguet

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