Mar 27, 2020

How Early Life Adversity Influences Defensive Circuitry

Trends in Neurosciences
Sahana Murthy, Elizabeth Gould

Abstract

Childhood maltreatment increases the likelihood of developing anxiety disorders in humans. Early life adversity (ELA) paradigms in rodents produce lasting increases in avoidant and inhibitory responses to both immediate and nonspecific threats, collectively referred to as defensive behaviors. This approach provides an opportunity to thoroughly investigate the underlying mechanisms, an effort that is currently under way. In this review, we consider the growing literature indicating that ELA alters the rhythmic firing of neurons in brain regions associated with defensive behavior, as well as potential neuronal, glial, and extracellular matrix contributions to functional changes in this circuitry. We also consider how ELA studies in rodents may inform us about both susceptible and resilient outcomes in humans.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Neurons
Brain Region
Literature
Anxiety Disorders
Neuroglia
Rhythmic Process (Biological)
Rodent
PhenX Measure - Childhood Maltreatment
Extracellular Matrix
Study

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Martha M C ElwenspoekClaude P Muller
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
D K Prusator, Beverley Greenwood-Van Meerveld
© 2020 Meta ULC. All rights reserved