How estrogen-specific proteins discriminate estrogens from androgens: a common steroid binding site architecture

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Virginie NahoumSheng-Xiang Lin

Abstract

Steroid hormones play an essential role in a wide range of physiological and pathological processes, such as growth, metabolism, aging, and hormone-sensitive cancers. Estrogens are no exception and influence growth, differentiation, and functioning of many target tissues, such as the mammary gland, uterus, hypothalamus, pituitary, bone, and liver. Although very similar in structure, each steroid class (i.e., estrogens, androgens, progestins, mineral corticoids, or glucocorticoids) is responsible for distinct physiological processes. To permit specific biological responses for a given steroid class, specific proteins are responsible for steroid bioactivation, action, and inactivation, yet they have low or no affinity to other classes. Estrogens make no exception and possess their own set of related proteins. To understand the molecular basis underlying estrogen recognition from other steroids, structural features of estrogen-specific proteins were analyzed along with their ability to discriminate between steroid hormones belonging to different classes. Hence, the study of all estrogen-specific proteins for which an atomic structure has been determined demonstrated that a common steroid-binding pocket architecture is shared by th...Continue Reading

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Citations

Jun 17, 2009·BMC Bioinformatics·Gabriele AusielloManuela Helmer-Citterich
Mar 1, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Mahder Seifu ManendaRong Shi
Feb 3, 2007·Biochemical Pharmacology·Smarajit MaitiGuangping Chen
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Oct 7, 2004·Biopolymers·Roni KasherFortune Kohen
Nov 23, 2010·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jelle ReinenNico P E Vermeulen

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