How exercise may amend metabolic disturbances in diabetic cardiomyopathy

Antioxidants & Redox Signaling
Anne D HafstadEllen Aasum

Abstract

Over-nutrition and sedentary lifestyle has led to a worldwide increase in obesity, insulin resistance, and type 2 diabetes (T2D) associated with an increased risk of development of cardiovascular disorders. Diabetic cardiomyopathy, independent of hypertension or coronary disease, is induced by a range of systemic changes and may through multiple processes result in functional and structural cardiac derangements. The pathogenesis of this cardiomyopathy is complex and multifactorial, and it will eventually lead to reduced cardiac working capacity and increased susceptibility to ischemic injury. Metabolic disturbances such as altered lipid handling and substrate utilization, decreased mechanical efficiency, mitochondrial dysfunction, disturbances in nonoxidative glucose pathways, and increased oxidative stress are hallmarks of diabetic cardiomyopathy. Interestingly, several of these disturbances are found to precede the development of cardiac dysfunction. Exercise training is effective in the prevention and treatment of obesity and T2D. In addition to its beneficial influence on diabetes/obesity-related systemic changes, it may also amend many of the metabolic disturbances characterizing the diabetic myocardium. These changes are ...Continue Reading

References

Jul 1, 1992·Journal of Applied Physiology·D J PaulsonJ Zhao
Sep 1, 1991·The American Journal of Physiology·D BurkhoffG Gerstenblith
Apr 1, 1990·Physiological Reviews·H Suga
Jul 1, 1971·The Journal of Clinical Investigation·O D Mjos
Nov 1, 1982·Basic Research in Cardiology·C E HeyligerN S Dhalla
Feb 1, 1994·Cardiovascular Drugs and Therapy·F S Fein, E H Sonnenblick
May 1, 1997·The Journal of Clinical Investigation·M HawkinsL Rossetti
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·H WakasakiG L King
May 7, 1998·The Journal of Membrane Biology·K R Eager, A F Dulhunty
Dec 11, 1999·Medicine and Science in Sports and Exercise·S N Blair, S Brodney
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·D D BelkeD L Severson
Jan 11, 2000·Circulation Research·A FrustaciP Anversa
Apr 4, 2001·The Journal of Clinical Investigation·H C ChiuJ E Schaffer
Jan 5, 2002·Diabetes·Qiangrong LiangPaul N Epstein
Mar 15, 2002·The New England Journal of Medicine·Jonathan MyersJ Edwin Atwood
May 16, 2002·Biochimica Et Biophysica Acta·Kazim Husain, Stephen R Hazelrigg
Jun 5, 2002·Congestive Heart Failure·Gaurav Choudhary, Samuel C Dudley
Aug 7, 2002·Circulation·Terence KavanaghRoy J Shephard
Oct 10, 2002·The Journal of Biological Chemistry·Karim S EchtayMartin D Brand
Oct 24, 2002·Journal of Molecular and Cellular Cardiology·Robert S Balaban
Jun 18, 2003·Circulation·Michaela Scheuermann-FreestoneKieran Clarke
Aug 28, 2003·The Journal of Biological Chemistry·Raymond J ClarkWolfgang H Dillmann
Oct 9, 2003·The Journal of Laboratory and Clinical Medicine·Yakup AliciguzelUmit Karayalcin
Oct 14, 2003·Cardiovascular Toxicology·Lu Cai, Y James Kang
Apr 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Yan BurelleMichael F Allard
Apr 28, 2004·Free Radical Biology & Medicine·Anil K Jaiswal
Jul 29, 2004·American Journal of Physiology. Endocrinology and Metabolism·Xia ShenPaul N Epstein
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Tom L BroderickMelissa Gillis
Nov 6, 2004·Current Hypertension Reports·Darrell D Belke, Wolfgang H Dillmann
Dec 25, 2004·Circulation Research·Hsiu-Chiang ChiuJean E Schaffer

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Citations

Mar 27, 2015·Antioxidants & Redox Signaling·Vera B Schrauwen-HinderlingPatrick Schrauwen
Jun 25, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Kevin C Dellsperger
Nov 10, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Yin KangBradley B Keller
Dec 17, 2019·Acta Physiologica·Marina Makrecka-KukaTerje S Larsen
Sep 9, 2017·Journal of Applied Physiology·Dalila BoudiaJane-Lise Samuel
Jul 1, 2016·Clinical Science·Miguel A AonSteven J Sollott
Oct 22, 2019·Frontiers in Physiology·Neoma T BoardmanEllen Aasum
Jun 23, 2018·Frontiers in Cardiovascular Medicine·Stephen C Kolwicz
Dec 18, 2019·International Journal of Molecular Sciences·Dae Yun SeoJin Han
Aug 17, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Neoma T BoardmanEllen Aasum
Aug 13, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Neoma T BoardmanEllen Aasum
Sep 5, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Addisu Dabi Wake
Mar 27, 2020·Frontiers in Physiology·Larissa VetterFelix T Kurz
Aug 23, 2020·Medicine and Science in Sports and Exercise·Shengcun LiSonghe Jiang
Jan 6, 2021·Npj Aging and Mechanisms of Disease·Miguel A AonSteven J Sollott
Aug 14, 2020·Journal of Agricultural and Food Chemistry·Yipin LuHaoyi Ren
Sep 4, 2021·Cardiovascular Research·Fabian Sanchis-GomarSteven N Blair

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