PMID: 6397386Dec 1, 1984Paper

How glucagon-like is glucagon-like peptide-1?

Diabetologia
M GhiglioneS R Bloom

Abstract

Although glucagon-like peptide-1 has the appearance of a glucagon-homologue that may be co-secreted with glucagon, synthetic glucagon-like peptide-1-(1-37) does not significantly affect plasma glucose and insulin concentrations when administered at high doses (100 and 400 micrograms) to cortisone-pretreated rabbits. This synthetic preparation thus lacks the primary metabolic effect of glucagon at the doses tested. An intra- or extra-pancreatic role of glucagon-like peptide-1 has yet to be discovered.

References

Jun 1, 1969·Diabetologia·F TardingA V Nielsen
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L C LopezG F Saunders

❮ Previous
Next ❯

Citations

Aug 1, 1988·Regulatory Peptides·K ShimaC Ohboshi
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D J DruckerJ F Habener
Apr 1, 1991·European Journal of Clinical Investigation·R GökeB Göke
Jun 14, 2012·Endocrine-related Cancer·Roman VangoitsenhovenBart Van der Schueren
Sep 18, 2013·Diabetes, Obesity & Metabolism·D RondasC Mathieu
Mar 23, 2005·Regulatory Peptides·Tanya Hansotia, Daniel J Drucker
Feb 27, 1987·Biochemical and Biophysical Research Communications·N M HooseinR S Gurd
Jan 1, 1987·Diabetes/metabolism Reviews·R Ebert, W Creutzfeldt
Dec 5, 2017·The Journal of Clinical Investigation·Daniel J DruckerJens Juul Holst
Dec 22, 1999·Endocrine Reviews·T J Kieffer, J F Habener
Jun 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rafael R SchickVolker Schusdziarra
Nov 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Cecilie EgholmSteen Dissing

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.