How haemophilia A impacts severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) treatment: a case report

Journal of Thrombosis and Thrombolysis
Ezio ZanonPaolo Simioni

Abstract

The typical symptoms of COVID-19 mimic those of the common season flu. In addition, several changes in the coagulation processes have been observed. To date, it's not fully clear how COVID-19 may affect patients with hereditary bleeding disorders. Anticoagulation in patients with haemophilia is still debated, but in this case could be needed. We are reporting a case of an elderly patient with mild haemophilia A hospitalized for Sars-Cov-2. On the 15th day of hospitalization, we observed an increase of all coagulation parameters. An antithrombotic prophylaxis at low dosage was immediately started, then increased at prophylactic dosage. Even if much more data are needed to ascertain the real thrombotic risk of haemophilia A in COVID-19 patients, it's clear that the FVIII and vWF should be strictly monitored in order to promptly establish an adequate treatment and avoid the onset of thromboembolic events, even fatal, causing many deaths in COVID-19 patients.

References

Mar 27, 2020·Journal of Thrombosis and Haemostasis : JTH·David Lillicrap
Apr 2, 2020·Viruses·Yuefei JinGuangcai Duan
Apr 3, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Dongyan CuiQun Hu
Apr 5, 2020·Journal of Thrombosis and Thrombolysis·Shiyu YinNing Tang
Apr 14, 2020·American Journal of Hematology·Evangelos TerposMeletios A Dimopoulos

❮ Previous
Next ❯

Citations

May 14, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Antonella ColucciaUNKNOWN AICE MECCOVID-19 Study Group

❮ Previous
Next ❯

Software Mentioned

EXTEM
INTEM
FIBTEM

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Haemophilia : the Official Journal of the World Federation of Hemophilia
Dongyan CuiQun Hu
British Medical Journal
C R Francis
Proceedings of the Royal Society of Medicine
E Pritchard
SA Nursing Journal. SA Verplegingstydskrif
J Kilpatrick, J Sissons
The Nursing Journal of India
A T Alencherry
© 2021 Meta ULC. All rights reserved