How has proteomics informed transfusion biology so far?

Critical Reviews in Oncology/hematology
Giancarlo LiumbrunoLello Zolla

Abstract

Since the genomic era has not fully kept its promises, studies addressing the protein complement to the genome have been recently gaining momentum. Proteomics investigations could be potentially used from bench to bedside, in order to test the quality of collected blood components prior to or during storage. In parallel, proteomics could be used to verify the effects of the production and pathogen reduction processes of plasma derivatives and blood components on the protein fractions, or to reduce the effects of storage lesions. Another area of interest is represented by the discovery of peculiar biomarkers readily adoptable for targeted evaluation of blood-component integrity or functionality, as well as to assess the proliferative capacity of hematopoietic stem/progenitor cells. These accumulating basic research evidences will hopefully be accompanied by actual applications in routine clinical practice. Whether the costs of the needed facilities (instruments and trained personnel) will meet the current demand of the clinical market, proteomic-expert transfusionists will no longer only inform, but also perform a role in clinical routine.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·L Anderson, N G Anderson
Apr 1, 1989·Kidney International·J A Schifferli, R P Taylor
Jan 1, 1980·Annual Review of Medicine·S J Slichter
Jul 1, 1995·Electrophoresis·V C WasingerI Humphery-Smith
Apr 1, 1997·Transfusion Medicine Reviews·J Seghatchian, P Krailadsiri
Mar 1, 1997·Electrophoresis·L Anderson, J Seilhamer
Mar 3, 1998·Vox Sanguinis·J P AuBuchonE Lee
Sep 18, 1998·Electrophoresis·N L Anderson, N G Anderson
May 29, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·R RichterW G Forssmann
Mar 22, 2000·Electrophoresis·M Boussac, J Garin
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Apr 17, 2001·Current Opinion in Hematology·K HübelW C Liles
Nov 17, 2001·JAMA : the Journal of the American Medical Association·G SubramanianS Broder
Feb 15, 2002·Current Opinion in Hematology·Mark J KouryStephen J Brandt
Feb 20, 2002·Trends in Biochemical Sciences·Juri Rappsilber, Matthias Mann
Mar 29, 2002·Proteomics·Eric E O'NeillHolger F Hebestreit
Jul 12, 2002·Proteomics·Patricia B MaguireDesmond J Fitzgerald
Dec 19, 2002·Molecular & Cellular Proteomics : MCP·N Leigh Anderson, Norman G Anderson
Aug 9, 2003·Analytical and Bioanalytical Chemistry·Katrin MarcusHelmut E Meyer
Aug 29, 2003·Biochemical and Biophysical Research Communications·Ming JiangZhihong Zhang
Oct 3, 2003·Biochemical and Biophysical Research Communications·Christoph ZenzmaierAndreas J Kungl
Oct 7, 2003·Annual Review of Biochemistry·Heng ZhuMichael Snyder
Nov 25, 2003·Hematology·Rita M BrazielLance A Liotta
Dec 3, 2003·Molecular & Cellular Proteomics : MCP·J P McRedmondD J Fitzgerald
Dec 4, 2003·Bone Marrow Transplantation·K Theilgaard-MönchE Dickmeiss

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Citations

May 25, 2010·Analytical and Bioanalytical Chemistry·Angelo D'Alessandro, Lello Zolla
Apr 17, 2013·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·P-M Mertes, K Boudjedir
Apr 8, 2011·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·N LionJ-D Tissot
Dec 24, 2010·Vox Sanguinis·D V Devine, P Schubert
Jul 17, 2013·Experimental Biology and Medicine·Steven R GoodmanMarko Zivanic
Nov 18, 2011·Expert Review of Proteomics·Michel PrudentNiels Lion

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