How I treat and monitor viral hepatitis B infection in patients receiving intensive immunosuppressive therapies or undergoing hematopoietic stem cell transplantation

Blood
Raymond Liang

Abstract

Hepatitis B virus (HBV) reactivation is a serious but preventable complication of immunosuppression. Full HBV serologic profile must be obtained from all patients receiving intensive immunosuppressive therapy. In general, preemptive anti-HBV therapy is more effective than giving treatment after development of reactivation. Prompt lamivudine therapy should be given to at-risk patients who are hepatitis B surface antigen (HBsAg)-positive. It is recommended that lamivudine be continued until at least 6 months after the cessation of immunosuppression. Some patients requiring a longer duration of lamivudine therapy are at risk of developing drug resistance. The newer anti-HBV agents are effective in overcoming lamivudine resistance. Early use of these agents may be considered. HBV reactivation was observed in HBsAg-negative patients with occult HBV infection (HBV DNA-positive) who are on heavy immunosuppression. The optimal management of this group of patients is unclear. For patients receiving allogeneic HSC transplants, the HBV status of the donors requires special attention. To minimize the risk of transmission of infection to recipients, HBsAg-positive donors should receive adequate anti-HBV therapy before HSC donation. As the r...Continue Reading

References

Jul 1, 1975·Chest·A MadrazoC B Lauter
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L T SohY W Ong
Sep 1, 1990·Hematological Oncology·R H LiangE K Chiu
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W F CarmanH C Thomas
Sep 1, 1991·Chest·J S BagleyG L Blackburn
Sep 1, 1987·American Journal of Epidemiology·A S LokH J Lin
Jun 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G K LauS K Lam
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M I AllenL D Condreay
Jul 9, 1998·The New England Journal of Medicine·C L LaiD F Gray
Feb 6, 1999·The American Journal of Gastroenterology·A Ahmed, E B Keeffe
Apr 10, 1999·Journal of Gastroenterology and Hepatology·G K LauR Liang
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R LiangY L Kwong
Oct 26, 1999·Critical Reviews in Oncology/hematology·G K LauR Liang
Feb 24, 2001·Journal of Gastroenterology and Hepatology·M KuniyoshiK Muta
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George K K LauRaymond Liang
Sep 19, 2002·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Michiya Kobayashi
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ann-Lii ChengUNKNOWN Lymphoma Committee of Taiwan Cooperative Oncology Group
Feb 6, 2004·Radiation Protection Dosimetry·H Klein
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Winnie YeoPhilip J Johnson
Dec 21, 2004·Breast Cancer Research and Treatment·Winnie YeoPhilip J Johnson
Jan 18, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Chee-Kin HuiGeorge K K Lau
Feb 8, 2005·European Journal of Haematology·Emilio IannittoRosa D Stefano
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Chee-kin HuiGeorge K K Lau

❮ Previous
Next ❯

Citations

Nov 13, 2012·Annals of Hematology·Merih Kizil ÇakarSeren Özenirler
Oct 12, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Shih-Hung TsaiTsu-Yi Chao
May 19, 2010·Bone Marrow Transplantation·M HamadaniS M Devine
Jan 25, 2012·Nature Reviews. Clinical Oncology·Harrys A Torres, Marta Davila
Jun 14, 2012·Current Opinion in Oncology·Eric Tse, Yok-Lam Kwong
Dec 29, 2010·Hepatitis Research and Treatment·Yutaka TsutsumiMasahiro Imamura
Nov 12, 2013·BMC Cancer·Jessica P HwangMaria E Suarez-Almazor
Nov 19, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Simona UrbaniMassimo Franchini
Apr 10, 2010·World Journal of Gastroenterology : WJG·Ozcan CeneliGülsan Türköz Sucak
Apr 8, 2011·World Journal of Gastroenterology : WJG·María Luisa Manzano-Alonso, Gregorio Castellano-Tortajada
Oct 26, 2011·World Journal of Gastroenterology : WJG·Claudio M MastroianniVincenzo Vullo
May 9, 2012·World Journal of Gastroenterology : WJG·Hande H TuncerSamer A Al-Homsi
Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Suparno Chakrabarti, Somnath Mukherjee
Jul 20, 2010·Immunotherapy·Yutaka TsutsumiNobuo Masauzi
Aug 29, 2013·Future Oncology·Chan Y CheahJohn F Seymour
Oct 1, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P FrangeS Blanche
Aug 21, 2013·European Journal of Internal Medicine·Kamuran TurkerMedine Hascuhadar
Feb 25, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Françoise Lunel-FabianiAlexandra Ducancelle
Oct 11, 2014·Clinical Medicine : Journal of the Royal College of Physicians of London·Jessica Katharine DysonStuart McPherson
Apr 29, 2010·Current Rheumatology Reports·Nichola Cooper, James B Bussel
Oct 7, 2011·Expert Review of Anti-infective Therapy·Samuel E MosesMark A Zuckerman
May 14, 2014·Expert Opinion on Drug Safety·Peter Riedell, Kenneth R Carson
Dec 20, 2015·Gastroenterology·Jang-June ParkUNKNOWN HBRN
Sep 17, 2011·Clinics and Research in Hepatology and Gastroenterology·Panagiotis PapamichalisEirini I Rigopoulou
Dec 15, 2015·Expert Review of Hematology·Jasleen K Randhawa, Alessandra Ferrajoli
Apr 21, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maximilian ChristopeitGerhard Behre
Mar 31, 2010·Seminars in Hematology·Juan C Gea-Banacloche
Jul 17, 2009·British Journal of Haematology·Raymond Liang
Jul 14, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L MilazzoS Antinori
Feb 16, 2010·British Journal of Haematology·Nichola Cooper, Donald M Arnold

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