How I treat chronic lymphocytic leukemia in older patients

Journal of Geriatric Oncology
Bradley Heraly, Vicki A Morrison

Abstract

Chronic lymphocytic leukemia (CLL) is a disease predominantly of the elderly, with a median age at diagnosis of 72 years. Although many advances have been made in the care of these patients with the addition of a variety of active drugs to the therapeutic armamentarium, treatment in the elderly remains complicated by factors as comorbidities, functional status, and fitness, as well as under representation in many clinical trials. We will review the data on initial CLL treatment approaches, as well as therapy in the relapsed/refractory disease setting, with a focus on the elderly. We will also address the impact of comorbidities on treatment choices, and the importance of assessing the functional status and fitness of elderly patients when choosing appropriate therapies. Treatment recommendations for the older treatment naïve patient, both fit and less fit, as well as those receiving later therapies, will be summarized, with an emphasis not only on chronologic age, but also fitness for treatment.

References

Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
May 27, 2004·Expert Review of Anticancer Therapy·Catherine Terret
Aug 12, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G FreyerE Pujade-Lauraine
Mar 8, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicole LamannaMark A Weiss
Nov 8, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Asher Chanan-KhanMyron S Czuczman
Dec 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kenneth A FoonAhmad Tarhini
Feb 7, 2009·Leukemia & Lymphoma·Barbara EichhorstMichael Hallek
Jun 2, 2009·Cancer Treatment Reviews·Antonella BrunelloMartine Extermann
Aug 5, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang U KnaufMarco Montillo
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William G WierdaUNKNOWN Hx-CD20-406 Study Investigators
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thorsten ZenzStephan Stilgenbauer
Nov 26, 2010·Expert Review of Hematology·Lodovico Balducci
Dec 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine I ChenSuzanne Trudel
Feb 16, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer A WoyachJohn C Byrd
Mar 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arti HurriaHarvey Jay Cohen
Aug 17, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kirsten FischerClemens-Martin Wendtner
Aug 8, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kirsten FischerClemens-Martin Wendtner
Dec 28, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xavier C BadouxAlessandra Ferrajoli
Jun 21, 2013·The New England Journal of Medicine·John C ByrdSusan O'Brien

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Citations

Aug 6, 2016·Journal of Geriatric Oncology·Barbara EichhorstValentin Goede
Feb 27, 2016·The European Respiratory Journal·Eglantine HaustraeteAnne Bergeron

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