How I treat elderly patients with myeloma

Blood
Jayesh MehtaSeema Singhal

Abstract

The clinical approach to older patients with myeloma has to be modified to take into account comorbidities and the likelihood of higher treatment-related toxicity. Individualization of management and adequate supportive therapy are important to obtain the best response while minimizing adverse effects. Corticosteroids, novel agents, conventional cytotoxic agents, and high-dose chemotherapy with autotransplantation (modalities used in younger patients) are also used in older patients, although the elderly undergo transplantation less frequently. The sequential use of active agents singly and in different combinations has improved response rates and survival of all patients with myeloma, including the elderly.

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Citations

Apr 8, 2011·Expert Opinion on Investigational Drugs·Massimo OffidaniAntonio Palumbo
Oct 2, 2012·Journal of Geriatric Oncology·Tanya M WildesArti Hurria
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Mar 2, 2019·Current Hematologic Malignancy Reports·Saurabh ZanwarPrashant Kapoor
May 28, 2019·Current Oncology Reports·Crystal Antoine-Pepeljugoski, Marc Justin Braunstein

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