How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2

Annals of the New York Academy of Sciences
Stephen G Brohawn

Abstract

The ability to sense and respond to mechanical forces is essential for life and cells have evolved a variety of systems to convert physical forces into cellular signals. Within this repertoire are the mechanosensitive ion channels, proteins that play critical roles in mechanosensation by transducing forces into ionic currents across cellular membranes. Understanding how these channels work, particularly in animals, remains a major focus of study. Here, I review the current understanding of force gating for a family of metazoan mechanosensitive ion channels, the two-pore domain K(+) channels (K2Ps) TRAAK, TREK1, and TREK2. Structural and functional insights have led to a physical model for mechanical activation of these channels. This model of force sensation by K2Ps is compared to force sensation by bacterial mechanosensitive ion channels MscL and MscS to highlight principles shared among these evolutionarily unrelated channels, as well as differences of potential functional relevance. Recent advances address fundamental questions and stimulate new ideas about these unique mechanosensors.

References

Aug 4, 1998·The EMBO Journal·A J PatelM Lazdunski
Sep 10, 1999·The Journal of Biological Chemistry·F MaingretE Honoré
Apr 5, 2000·The Journal of Biological Chemistry·H BangD Kim
Jun 3, 2000·The EMBO Journal·F MaingretE Honoré
Jun 27, 2000·Biophysical Journal·W RawiczE Evans
May 31, 2002·Nature·Youxing JiangRoderick MacKinnon
Jun 4, 2004·The EMBO Journal·C HeurteauxM Lazdunski
Dec 4, 2004·The EMBO Journal·Jean CheminEric Honoré
Jan 29, 2005·The Journal of Physiology·Dawon KangDonghee Kim
Jul 12, 2005·The Journal of Biological Chemistry·Janet MurbartiánDouglas A Bayliss
Oct 22, 2005·The Journal of Physiology·Kenton M Sanders, Sang Don Koh
Apr 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Eric HonoréFrederick Sachs
May 6, 2006·The EMBO Journal·Abdelkrim AllouiMichel Lazdunski
Aug 15, 2006·Nature Neuroscience·Catherine HeurteauxMichel Lazdunski
Mar 22, 2007·Nature Reviews. Neuroscience·Eric Honoré
Mar 13, 2009·The EMBO Journal·Jacques NoëlMichel Lazdunski
May 1, 2009·European Biophysics Journal : EBJ·Asi CohenNoam Zilberberg
May 22, 2009·Nature·Rob PhillipsPierre Sens
Mar 3, 2010·Annual Review of Biophysics·Jóhanna Arnadóttir, Martin Chalfie
Apr 16, 2010·Physiological Reviews·Péter Enyedi, Gábor Czirják
Aug 3, 2010·Nature Structural & Molecular Biology·Sheng YeYouxing Jiang
Sep 10, 2010·Annual Review of Microbiology·Ching KungSergei Sukharev
Jan 13, 2011·The Journal of Physiology·Kevin MonaghanSang Don Koh
Jan 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Guillaume SandozEhud Y Isacoff
Jul 19, 2011·The EMBO Journal·Sviatoslav N BagriantsevDaniel L Minor
Aug 9, 2011·The EMBO Journal·Paula L PiechottaThomas Baukrowitz
Aug 11, 2011·Channels·Jacques NoëlFlorian Lesage
Aug 31, 2011·The Journal of General Physiology·Diana M Bautista, Ellen A Lumpkin
Oct 18, 2011·Structure·Elizabeth S HaswellDouglas C Rees
Nov 30, 2011·The Journal of General Physiology·Zhenwei SuYoshiro Saimi
Jan 28, 2012·Science·Alexandria N Miller, Stephen B Long

❮ Previous
Next ❯

Citations

Oct 26, 2016·Protein Science : a Publication of the Protein Society·Xuejun C ZhangJie Li
Nov 23, 2018·Biological Chemistry·Verena KanoldtCarsten Grashoff
Mar 1, 2017·EMBO Molecular Medicine·Niels DecherEric Schulze-Bahr
Sep 23, 2019·Pediatric Surgery International·Anne-Marie O'DonnellPrem Puri
Feb 23, 2018·Nature·Yuh Nung Jan, Lily Yeh Jan
Feb 23, 2020·Annual Review of Neuroscience·Peng JinYuh-Nung Jan
Jul 4, 2018·Scientific Reports·Wynn LegonJerel K Mueller
Feb 1, 2018·Nature·Yuh Nung Jan, Lily Yeh Jan
Aug 17, 2016·Biochemical Society Transactions·Tim Rasmussen
Apr 30, 2019·Frontiers in Pharmacology·Alaeddine DjillaniMarc Borsotto
May 30, 2019·International Journal of Molecular Sciences·Isabella SalzerStefan Boehm
Feb 8, 2018·Physiological Reviews·Natalia PrevarskayaYaroslav Shuba
Dec 18, 2020·Biophysical Journal·Rajitha Rajeshwar TJuan M Vanegas
Jun 20, 2020·Progress in Biophysics and Molecular Biology·Felix WiedmannConstanze Schmidt
Nov 2, 2019·Biochimica Et Biophysica Acta. Biomembranes·E Nicholas PetersenScott B Hansen
Nov 18, 2020·Nature Chemical Biology·Mackenzie J Thompson, John E Baenziger
Feb 18, 2021·European Journal of Human Genetics : EJHG·Karen W GrippKerstin Kutsche
Jul 28, 2017·Current Opinion in Plant Biology·Debarati Basu, Elizabeth S Haswell
Jul 16, 2020·The Journal of Physical Chemistry. B·Conner M WinkeljohnJuan M Vanegas

❮ Previous
Next ❯

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