PMID: 9545081Apr 17, 1998Paper

How is membrane phospholipid biosynthesis controlled in neural tissues?

Journal of Neuroscience Research
W Araki, R J Wurtman

Abstract

Phospholipids are the major constituents of cell membranes, and have numerous structural and functional roles in the nervous system. Although the metabolic pathways responsible for the syntheses of the phosphatides phosphatidylcholine (PtdCho), phosphatidylethanolamine (PtdEtn), and phosphatidylserine (PtdSer) are well understood, the mechanisms controlling these pathways in neural tissue have not been fully characterized. Recent studies have suggested that the main factors controlling PtdCho and PtdEtn synthesis by the Kennedy cycle tend to be the intracellular levels of key substrates for the biosynthetic enzymes, or changes in the activities of the rate-limiting enzymes. Moreover, different control mechanisms may operate, depending upon the functional state of the tissue.

Citations

Jan 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sujung J YoonPerry F Renshaw
Jun 17, 2004·Journal of Neurochemistry·Rosaria BuccolieroAnthony H Futerman
Aug 26, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P J Kamphuis, R J Wurtman
Jun 17, 2005·Lipids·Mikhail Y GolovkoEric J Murphy
Dec 13, 2006·The European Journal of Neuroscience·John P BrunoGreg A Gerhardt
Jan 15, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Seyed Khosrow Tayebati, Francesco Amenta
Sep 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jacques BodennecAnthony H Futerman
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Apr 26, 2006·Cellular and Molecular Neurobiology·Ismail H UlusRichard J Wurtman
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Apr 23, 2003·Brain Research·U Ingrid RichardsonRichard J Wurtman
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lisa A Teather, Richard J Wurtman
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Jun 28, 2005·Neurochemistry International·Eduardo Garbarino-PicoMario E Guido
Apr 1, 2008·European Journal of Pharmacology·Eline M van der Beek, Patrick J G H Kamphuis

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