How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays.

Seminars in Cell & Developmental Biology
Linda Wordeman

Abstract

Kinesins are enzymes that use the energy of ATP to perform mechanical work. There are approximately 14 families of kinesins within the kinesin superfamily. Family classification is derived primarily from alignments of the sequences of the core motor domain. For this reason, the enzymatic behavior and motility of each motor generally reflects its family. At the cellular level, kinesin motors perform a variety of functions during cell division and within the mitotic spindle to ensure that chromosomes are segregated with the highest fidelity possible. The cellular functions of these motors are intimately related to their mechanical and enzymatic properties at the single molecule level. For this reason, motility studies designed to evaluate the activity of purified molecular motors are a requirement in order to understand, mechanistically, how these motors make the mitotic spindle work and what can cause the spindle to fail. This review will focus on a selection of illustrative kinesins, which have been studied at the molecular level in order to inform our understanding of their function in cells. In addition, the review will endeavor to point out some kinesins that have been studied extensively but which still lack sufficient mole...Continue Reading

Citations

Feb 22, 2011·Annual Review of Biophysics·Kristen J VerheyVirupakshi Soppina
Oct 12, 2010·Journal of Cell Science·Sharyn A EndowHonglei Liu
Jun 8, 2011·PloS One·Mary Kate BonnerAhna R Skop
Jan 10, 2012·Cell Death and Differentiation·E ManchadoM Malumbres
Jan 3, 2016·Experimental Hematology·Isuzu KobayashiWataru Nunomura
Mar 16, 2016·Future Medicinal Chemistry·Stephanie M Myers, Ian Collins
Feb 27, 2013·Cancer Science·Xinran LiuKun Huang
Jul 15, 2015·Journal of Theoretical Biology·D WhiteA Dawes
Jul 23, 2013·Biochemical and Biophysical Research Communications·Houbao ZhuZhugang Wang
Sep 23, 2011·Biochemical Society Transactions·David VannesteIsabelle Vernos
Feb 7, 2012·Archives of Biochemistry and Biophysics·Virgil Muresan, Zoia Muresan
Nov 10, 2013·Current Biology : CB·Emma G Sturgill, Ryoma Ohi
Mar 1, 2015·Cancer Letters·Sergey O Tcherniuk, Andrew V Oleinikov
Oct 5, 2014·Cellular and Molecular Life Sciences : CMLS·Ling GuQiang Wang
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Michael W PanasWilliam R Jacobs
Aug 31, 2013·PloS One·Elizabeth J Lawrence, Craig A Mandato
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Veronika BrynychovaPavel Soucek
Sep 21, 2012·Acta Crystallographica. Section D, Biological Crystallography·S K TalapatraF Kozielski
Jan 5, 2017·Nature Communications·Andrew R PopchockWeihong Qiu
Apr 22, 2017·Human Reproduction Update·Nicole J CamlinJanet E Holt
Jul 3, 2017·Journal of Cell Science·Zhen-Yu She, Wan-Xi Yang
Mar 17, 2018·Human Molecular Genetics·Antonella SferraEnrico Bertini
Jun 30, 2012·Molecular Biology of the Cell·Eric Karsenti
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Julia LockeCarolyn A Moores
Oct 25, 2017·Journal of Biomolecular Structure & Dynamics·Chandrasekaran BalakumarRajshekhar Karpoormath
Dec 16, 2017·Scientific Reports·Anna GieryngBozena Kaminska
Oct 20, 2018·The Journal of Biological Chemistry·Mingyao MengZongliu Hou
Jul 25, 2012·Nature Reviews. Cancer·Oliver Rath, Frank Kozielski
Apr 18, 2019·Cancers·Gerhard JungwirthChristel Herold-Mende
May 9, 2019·Molecular Biology of the Cell·Carissa M Heath, Sarah M Wignall
Dec 10, 2019·Expert Opinion on Investigational Drugs·Esperanza Macarena AlgarínEnrique M Ocio

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