How Leucocyte Cell Membrane Modified Janus Microcapsules are Phagocytosed by Cancer Cells

ACS Applied Materials & Interfaces
Wenping HeQiang He

Abstract

Modern drug delivery systems rely on either antibody-based single-surface recognition or on surface-hydrophobicity-based approaches. For a tumor showing various surface mutations, both approaches fail. This publication hereby presents Janus capsules based on polyelectrolyte multilayer microcapsules exhibiting human leucocyte (THP-1 cell line) cell membranes for discriminating HUVEC cells from three different cancer cell lines. Despite destroying the cellular integrity of leucocyte cells, the modified Janus capsules are able to adhere to cancer cells. Leucocyte cell-membrane-coated Janus capsules are phagocytosed with the cellular membrane part pointing to the cells.

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Citations

Mar 30, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Wenping HeQiang He
May 19, 2016·Advanced Healthcare Materials·Lang RaoXing-Zhong Zhao
Apr 1, 2017·Therapeutic Delivery·Mariacristina Gagliardi
Oct 3, 2017·Nanomedicine·Ashwin NarainYogita Patil-Sen
Sep 5, 2018·Nanoscale·Amir Masoud Pourrahimi, Martin Pumera
Feb 12, 2019·Expert Opinion on Drug Delivery·Hai ZouDong-Sheng Huang
Oct 17, 2019·Pharmaceutics·Veena VijayanIn-Kyu Park
Sep 12, 2020·Nanoscale·Reshma KadamKurosch Rezwan
May 27, 2016·Bioengineering & Translational Medicine·Diana DehainiLiangfang Zhang
Dec 2, 2017·Advanced Healthcare Materials·Alexander S TiminGleb B Sukhorukov
May 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zahid HussainMohammed A S Abourehab
Oct 14, 2021·Macromolecular Bioscience·Veronika Kozlovskaya, Eugenia Kharlampieva

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