How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets

Frontiers in Immunology
Haiguang Wang, Kristin A Hogquist

Abstract

In contrast to peptide-recognizing T cells, invariant natural killer T (iNKT) cells express a semi-invariant T cell receptor that specifically recognizes self- or foreign-lipids presented by CD1d molecules. There are three major functionally distinct effector states for iNKT cells. Owning to these innate-like effector states, iNKT cells have been implicated in early protective immunity against pathogens. Yet, growing evidence suggests that iNKT cells play a role in tissue homeostasis as well. In this review, we discuss current knowledge about the underlying mechanisms that regulate the effector states of iNKT subsets, with a highlight on the roles of a variety of transcription factors and describe how each subset influences different facets of thymus homeostasis.

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Citations

Feb 20, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Henrique Borges da SilvaStephen C Jameson
Oct 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Haiguang WangKristin A Hogquist
Jul 14, 2020·Frontiers in Immunology·Tonya J WebbPaolo Dellabona
Mar 13, 2019·Nature Immunology·Shankar S IyerRichard S Blumberg
Oct 22, 2019·European Journal of Immunology·Andrea CossarizzaArturo Zychlinsky
Jun 4, 2020·International Journal of Molecular Sciences·Angélica Díaz-BasabeFederica Facciotti
Jul 16, 2019·The EMBO Journal·Eleanor Clancy-ThompsonStephanie K Dougan
Mar 10, 2020·F1000Research·Kristin Hogquist, Hristo Georgiev
Jul 25, 2020·Mucosal Immunology·Qiaochu LinThierry Mallevaey
Dec 12, 2020·Seminars in Immunopathology·Emilie J CoswayAndrea J White
Dec 29, 2020·Molecular Immunology·Elizabeth A Leadbetter, Mikael C I Karlsson
Jan 14, 2021·Immunological Reviews·Elizabeth A Leadbetter, Mikael C I Karlsson
Jan 29, 2021·Journal of Immunology Research·Nilberto Dias de AraújoAllyson Guimarães Costa
Feb 2, 2021·European Journal of Immunology·S Thera LeeKristin A Hogquist
Mar 16, 2021·Immunometabolism·Emily L YaroszAjay Kumar
Nov 30, 2018·Molecular Immunology·Ageliki Tsagaratou

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Methods Mentioned

BETA
RNA-seq
PCA
Chip-Seq
ubiquitination
nuclear magnetic resonance

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