How little do we actually know? On the size of gene regulatory networks

IEEE/ACM Transactions on Computational Biology and Bioinformatics
Richard RöttgerJan Baumbach

Abstract

The National Center for Biotechnology Information (NCBI) recently announced the availability of whole genome sequences for more than 1,000 species. And the number of sequenced individual organisms is growing. Ongoing improvement of DNA sequencing technology will further contribute to this, enabling large-scale evolution and population genetics studies. However, the availability of sequence information is only the first step in understanding how cells survive, reproduce, and adjust their behavior. The genetic control behind organized development and adaptation of complex organisms still remains widely undetermined. One major molecular control mechanism is transcriptional gene regulation. The direct juxtaposition of the total number of sequenced species to the handful of model organisms with known regulations is surprising. Here, we investigate how little we even know about these model organisms. We aim to predict the sizes of the whole-organism regulatory networks of seven species. In particular, we provide statistical lower bounds for the expected number of regulations. For Escherichia coli we estimate at most 37 percent of the expected gene regulatory interactions to be already discovered, 24 percent for Bacillus subtilis, and...Continue Reading

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Citations

Aug 7, 2013·Nature Communications·Ngoc Hieu TranLouxin Zhang
Jul 17, 2014·Bioinformatics·Mushthofa MushthofaMartine De Cock
Oct 31, 2013·Nucleic Acids Research·Robyn T EijlanderOscar P Kuipers
Sep 12, 2015·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Pei WangXinghuo Yu
May 7, 2016·Nucleic Acids Research·Markus ListJan Baumbach
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Mar 17, 2018·Nature Communications·Wouter SaelensYvan Saeys
May 13, 2020·Scientific Data·Mariana Teixeira Dornelles PariseJan Baumbach

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