How mammalian transcriptional repressors work

European Journal of Biochemistry
Gerald ThielMathias Hohl

Abstract

Research on the regulation of transcription in mammals initially focused on the mechanism of transcriptional activation and 'positive control' of gene regulation. In contrast, transcriptional repression and 'negative control' of gene transcription was viewed rather as part of the 'prokaryotic book of biology'. However, results obtained in recent years have shown convincingly that transcriptional repression mediated by repressor proteins is a common regulatory mechanism in mammals and may play a key role in many biological processes. In particular, the fact that human diseases, such as Rett and ICF syndromes as well as some human forms of cancer, are connected with the activities of human repressor proteins indicates that transcriptional repression and gene silencing is essential for maintenance of the cellular integrity of a multicellular organism. The wide range of diseases caused by aberration in transcriptional repression sheds light on the importance of understanding how mammalian transcriptional repressor proteins work.

References

Jul 26, 1990·Nature·M Ptashne, A A Gann
Jun 2, 1995·Cell·A D Johnson
Jan 1, 1994·Trends in Biochemical Sciences·I G Cowell
Feb 9, 1996·The Journal of Biological Chemistry·S SchochG Thiel
Apr 1, 1997·Trends in Biochemical Sciences·P A WadeA P Wolffe
Jun 10, 1998·Nature·T H Bestor
Oct 6, 1998·Annual Review of Biochemistry·J L Workman, R E Kingston
Oct 24, 1998·Genes & Development·J MoitraC Vinson
Dec 28, 1999·Trends in Cell Biology·R D Kornberg
Mar 1, 2000·Trends in Biochemical Sciences·H H Ng, A Bird
May 18, 2001·Trends in Cell Biology·T Jenuwein
Jun 23, 2001·Oncogene·R FerreiraA Harel-Bellan
Aug 3, 2001·Nature·S J NielsenT Kouzarides
Mar 15, 2002·Current Opinion in Genetics & Development·Shiv I S Grewal, Sarah C R Elgin
Mar 21, 2002·Nature Reviews. Cancer·P MarksW K Kelly
Apr 24, 2002·Experimental Cell Research·Giuseppe ServilloPaolo Sassone-Corsi
Jun 4, 2002·Current Opinion in Hematology·Ari Melnick, Jonathan D Licht
Aug 3, 2002·Oncogene·Adam R Karpf, David A Jones
Oct 26, 2002·Science·Victoria V LunyakMichael G Rosenfeld
Nov 13, 2002·The Journal of Biological Chemistry·Francois FuksTony Kouzarides
Apr 19, 2003·Science·François GaudetRudolf Jaenisch
Jan 6, 2004·Science·André VerdelDanesh Moazed

❮ Previous
Next ❯

Citations

May 22, 2008·Diabetologia·G Thiel, F Schuit
Jul 14, 2005·Nature Reviews. Genetics·Laura Lande-Diner, Howard Cedar
Oct 28, 2008·The Journal of Biological Chemistry·C James ChouJoel M Gottesfeld
Aug 29, 2013·Database : the Journal of Biological Databases and Curation·Sushil TripathiAstrid Lægreid
Feb 4, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sudin BhattacharyaQiang Zhang
Apr 23, 2008·Molecular Pharmacology·Vidula Dixit, Rudy L Juliano
Jun 2, 2006·Molecular and Cellular Biology·Hozumi MotohashiMasayuki Yamamoto
Apr 22, 2011·Journal of Hematology & Oncology·Xiaoxin S XuGan Wang
Aug 19, 2007·Breast Cancer Research : BCR·Felicity LoseAmanda B Spurdle
Dec 30, 2006·PLoS Biology·Leor S Weinberger, Thomas Shenk
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bin LiMark I Greene
Sep 15, 2011·Journal of Cell Science·Kizhakke M SathyanSupriya G Prasanth
Aug 11, 2005·Science's STKE : Signal Transduction Knowledge Environment·Inna Nusinzon, Curt M Horvath
Feb 14, 2012·Plant Science : an International Journal of Experimental Plant Biology·Agnieszka Kiełbowicz-Matuk
Aug 25, 2009·Current Opinion in Plant Biology·Naden T Krogan, Jeff A Long
Apr 21, 2007·Trends in Genetics : TIG·Florian M PaulerDenise P Barlow
Nov 3, 2005·The European Journal of Neuroscience·Mathias Hohl, Gerald Thiel
Dec 13, 2005·The FEBS Journal·Carlos Rodriguez-CasoRicard V Solé
Sep 25, 2008·Journal of Cellular Biochemistry·Sabine I MayerGerald Thiel
Apr 5, 2013·Evolution; International Journal of Organic Evolution·Kyoungmin RohStephen R Proulx
Jan 5, 2005·Micron : the International Research and Review Journal for Microscopy·Hesam DehghaniDavid P Bazett-Jones
Aug 21, 2007·Biochemical and Biophysical Research Communications·Xiantong XinLi Zhang
May 10, 2016·Nature Immunology·Rahul RoychoudhuriNicholas P Restifo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.