How many amyloid-β peptides can a neuron bind before it dies?

Journal of Neurochemistry
Lisa-Marie Munter

Abstract

This Editorial highlights a study by Jana and coworkers published in the current issue of Journal of Neurochemistry, in which the authors performed a detailed, quantitative analysis to identify the Aβ oligomer causing neuronal cell death. While most studies so far aimed to determine the Aβ oligomer with highest toxicity using preformed and characterized Aβ oligomers added to cell cultures, this study established an approach to analyze Aβ oligomers bound to primary neurons. This may shed new light on how oligomeric status changes at the cell surface and if minor oligomeric species may account for measured effects. The authors' procedure allows to monitor the effects of different Aβ oligomers in parallel, constituting an important advancement in the research field. Read the highlighted article 'Membrane bound tetramer and trimer Aβ oligomeric species correlate with toxicity towards cultured neurons' on page 594.

References

Jun 12, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anja HarmeierGerd Multhaup
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Mar 1, 2011·Journal of Neurochemistry·Fabiana A CaetanoMarco A M Prado
Jul 12, 2011·Neurobiology of Aging·Sophie SokolowKaren Hoppens Gylys
Nov 30, 2011·Journal of Neurochemistry·Megan E Larson, Sylvain E Lesné
Nov 27, 2015·Journal of Neurochemistry·Metta K JanaGiuseppe D Ciccotosto

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Citations

Oct 1, 2016·International Journal of Environmental Research and Public Health·Sarah P LoughranRodney J Croft

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