How many cardiac cycles must be measured to permit accurate RR, QT, and QTc estimates in conscious dogs?

Journal of Pharmacological and Toxicological Methods
Robert L HamlinBruce W Keene

Abstract

Electrocardiography is an essential tool to assess the liability of test articles to produce torsade de pointes. The number of cardiac cycles that must be measured from a dog to accurately characterize the relationship between RR and QT intervals, and thus assess this liability, is unknown. In this study, electrocardiograms (ECGs) were obtained from 12 conscious dogs with sinus rhythm. In each dog, RR and QT intervals were measured for 12 cardiac cycles. Measurements for each were then averaged over all 12 cycles, and those results compared to the average of both the initial 6 and 3 cycles, as well as to the middle cycle alone, for 12, 6, and 4 of the dogs. QTc was calculated by dividing each QT by the cube root of the preceding RR interval. We found no significant differences in the results of measurements of RR, QT, or QTc obtained from 12, 6, 3, or 1 cycle, whether from 12, 6, or 4 dogs. Intraobserver variability of ECG measurements was tested by having a single observer measure 10 copies of 12 different ECGs. The greatest coefficient of variation (S.D./mean) for the measurement of any ECG parameter was less than 2.5%. We conclude that measurements of RR and QT intervals made by a trained observer from 1 cardiac cycle accura...Continue Reading

References

Sep 30, 1999·The Veterinary Record·A S Davis, B J Middleton
Mar 10, 2001·Japanese Heart Journal·Y MurakawaR Nagai
May 17, 2003·Journal of Pharmacological and Toxicological Methods·Andrew J Batey, Christopher P A Doe

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Citations

Jun 13, 2012·The Journal of Toxicological Sciences·Anusak KijtawornratRobert L Hamlin
Feb 24, 2006·Journal of Pharmacological Sciences·Hiroyasu MiyazakiKeiji Yamamoto
Nov 23, 2006·European Journal of Pharmacology·Michael W SchmittIcilio Cavero
May 12, 2005·Journal of Pharmacological and Toxicological Methods·Marshall Leslie TattersallJean-Pierre Valentin
Mar 18, 2017·The Journal of Veterinary Medical Science·Anusak KijtawornratChollada Buranakarl
May 16, 2020·Journal of the American Animal Hospital Association·Simon P HagleyRobert Poppenga

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