How many ways a cell can move: the modes of self-propulsion of an active drop

Soft Matter
Aurore LoisyTanniemola B Liverpool

Abstract

Numerous physical models have been proposed to explain how cell motility emerges from internal activity, mostly focused on how crawling motion arises from internal processes. Here we offer a classification of self-propulsion mechanisms based on general physical principles, showing that crawling is not the only way for cells to move on a substrate. We consider a thin drop of active matter on a planar substrate and fully characterize its autonomous motion for all three possible sources of driving: (i) the stresses induced in the bulk by active components, which allow in particular tractionless motion, (ii) the self-propulsion of active components at the substrate, which gives rise to crawling motion, and (iii) a net capillary force, possibly self-generated, and coupled to internal activity. We determine travelling-wave solutions to the lubrication equations as a function of a dimensionless activity parameter for each mode of motion. Numerical simulations are used to characterize the drop motion over a wide range of activity magnitudes, and explicit analytical solutions in excellent agreement with the simulations are derived in the weak-activity regime.

References

Jan 16, 1999·Current Biology : CB·A B VerkhovskyG G Borisy
Oct 16, 1995·Physical Review Letters· Dos Santos FD, T Ondarçuhu
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John L TanChristopher S Chen
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Olivia du RoureBenoit Ladoux
Jul 11, 2006·Physical Biology·K KruseJ Prost
Jun 12, 1992·Science·M K Chaudhury, G M Whitesides
May 3, 2008·Nature·Tim LämmermannMichael Sixt
May 24, 2008·Nature·Kinneret KerenJulie A Theriot
Dec 31, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·L M Pismen, Jens Eggers
Apr 28, 2009·Physical Review Letters·Sumithra Sankararaman, Sriram Ramaswamy
Jun 16, 2009·Current Opinion in Cell Biology·Tim Lämmermann, Michael Sixt
Sep 28, 2010·Physical Review Letters·Danying ShaoHerbert Levine
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Renaud PoinclouxPhilippe Chavrier
Oct 21, 2011·Journal of the Royal Society, Interface·Falko ZiebertIgor S Aranson
Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Danying ShaoWouter-Jan Rappel
Jul 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Elsen TjhungMichael E Cates
Nov 9, 2012·Nature·Tim SanchezZvonimir Dogic
Feb 26, 2013·Trends in Biotechnology·Jafar HasanElena P Ivanova
Aug 28, 2013·The Journal of Cell Biology·Wei-Chien HungKonstantinos Konstantopoulos
Feb 18, 2014·The European Physical Journal. E, Soft Matter·Carl A WhitfieldRhoda J Hawkins
Apr 29, 2014·Physical Review Letters·Luca Giomi, Antonio DeSimone
Jul 1, 2014·Soft Matter·N KoumakisR Di Leonardo
Feb 15, 2013·Physical Review Letters·C Blanch-Mercader, J Casademunt
Aug 29, 2014·Physical Review Letters·P RechoL Truskinovsky
Jan 22, 2015·Nature Communications·E TjhungM E Cates
May 1, 2015·Journal of the Royal Society, Interface·W MarthA Voigt
Jul 22, 2015·Physical Review Letters·O SiposP Galajda
Jul 26, 2015·Physical Review Letters·Héctor Matías LópezEric Clément
Jan 15, 2016·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Diana Khoromskaia, Gareth P Alexander
Aug 9, 2016·Annual Review of Cell and Developmental Biology·Ewa K PaluchMichael Sixt
Jun 15, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Yuan Yuan, Yugen Zhang
Mar 16, 2018·Reports on Progress in Physics·Frank JülicherGuillaume Salbreux
Jun 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Shuo GuoXiang Cheng
Jul 26, 2018·Materials·Alexandra Muñoz-BonillaMarta Fernández-García
Jan 4, 2019·Proceedings. Mathematical, Physical, and Engineering Sciences·G KitavtsevB Wagner
Jan 11, 2020·Physical Review Letters·Aurore LoisyTanniemola B Liverpool

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Citations

Jul 22, 2020·Physical Review. E·Sarah TrinschekUwe Thiele
Jan 23, 2021·Soft Matter·Haiqin WangXinpeng Xu
Nov 9, 2021·Soft Matter·Christopher HenkelUwe Thiele

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