How mathematical modelling elucidates signalling in Bacillus subtilis

Molecular Microbiology
Ulf W LiebalOlaf Wolkenhauer

Abstract

Appropriate stimulus perception, signal processing and transduction ensure optimal adaptation of bacteria to environmental challenges. In the Gram-positive model bacterium Bacillus subtilis signalling networks and molecular interactions therein are well-studied, making this species a suitable candidate for the application of mathematical modelling. Here, we review systems biology approaches, focusing on chemotaxis, sporulation, σ(B) -dependent general stress response and competence. Processes like chemotaxis and Z-ring assembly depend critically on the subcellular localization of proteins. Environmental response strategies, including sporulation and competence, are characterized by phenotypic heterogeneity in isogenic cultures. The examples of mathematical modelling also include investigations that have demonstrated how operon structure and signalling dynamics are intricately interwoven to establish optimal responses. Our review illustrates that these interdisciplinary approaches offer new insights into the response of B. subtilis to environmental challenges. These case studies reveal modelling as a tool to increase the understanding of complex systems, to help formulating hypotheses and to guide the design of more directed exp...Continue Reading

References

Jul 7, 1977·Journal of Theoretical Biology·M EspinosaJ M Fernaud
Jul 1, 1975·Journal of Bacteriology·M G Sargent
Jan 1, 1992·Molecular Microbiology·D S Bischoff, G W Ordal
Jun 1, 1990·Journal of Bacteriology·L M MárquezM J Chamberlin
Jan 1, 1993·Antonie van Leeuwenhoek·A L Koch
Jan 1, 1995·Pharmacology & Therapeutics·L F Garrity, G W Ordal
Feb 5, 2000·Nature·M B Elowitz, S Leibler
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·P FawcettP Youngman
Dec 21, 2000·Current Opinion in Microbiology·A L Sonenshein
Jun 16, 2001·Advances in Microbial Physiology·M Hecker, U Völker
May 16, 2002·The Journal of Biological Chemistry·Christopher J Kristich, George W Ordal
Jan 28, 2003·Trends in Genetics : TIG·Jonathan Dworkin
Feb 11, 2003·Microbiology·Leendert W HamoenOscar P Kuipers
Aug 16, 2003·The Journal of Biological Chemistry·Hendrik SzurmantGeorge W Ordal
Jun 1, 1961·Journal of Molecular Biology·F JACOB, J MONOD
Dec 16, 2003·Journal of Molecular Biology·Martin Howard
Feb 12, 2004·Bulletin of Mathematical Biology·Hidde De JongMichel Page
Mar 24, 2004·Nature Reviews. Microbiology·Jeff Errington
Mar 25, 2004·Journal of Theoretical Biology·N B GroverL J H Koppes
Oct 7, 2004·Genetics·Christopher A VoigtAdam P Arkin
Nov 24, 2004·Molecular Microbiology·Peter J Lewis
Nov 24, 2004·Current Opinion in Microbiology·Patrick J Piggot, David W Hilbert
Jan 22, 2005·Molecular Microbiology·Daniel B KearnsRichard Losick
Feb 3, 2005·Journal of Bacteriology·Masaya FujitaRichard Losick
May 11, 2005·Cell·Jonathan Dworkin, Richard Losick
Jul 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Konstantin Doubrovinski, Martin Howard
Dec 17, 2005·Genes & Development·Daniel B Kearns, Richard Losick
Jan 25, 2006·Molecular Microbiology·Frances ChuRichard Losick
Mar 17, 2006·Nature Reviews. Microbiology·Wiep Klaas SmitsJan-Willem Veening
Mar 24, 2006·Nature·Gürol M SüelMichael B Elowitz
Apr 25, 2006·Cell·Bonnie L Bassler, Richard Losick
May 20, 2006·Nature·Dagmar IberIain D Campbell
Aug 2, 2006·Molecular Microbiology·David Dubnau, Richard Losick
Oct 14, 2006·Annual Review of Physical Chemistry·Daniel T Gillespie
Feb 6, 2007·Nature Reviews. Microbiology·Jean-Pierre Claverys, Leiv S Håvarstein
Mar 21, 2007·Molecular Microbiology·Madeleine LeisnerBerenike Maier
Mar 24, 2007·Science·Gürol M SüelMichael B Elowitz

❮ Previous
Next ❯

Citations

Jan 17, 2013·BMC Systems Biology·Ulf W LiebalOlaf Wolkenhauer
Jun 30, 2012·PloS One·Fordyce A DavidsonNicola R Stanley-Wall
Oct 31, 2013·Nucleic Acids Research·Robyn T EijlanderOscar P Kuipers
Mar 10, 2011·Mathematical Biosciences·Abhinav TiwariOleg A Igoshin
Mar 14, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Marcus J TindallJudith P Armitage
May 1, 2015·Frontiers in Microbiology·Pamela Lyon
Apr 19, 2012·Molecular BioSystems·Ulf W LiebalOlaf Wolkenhauer
Jun 18, 2020·Metabolites·Ulf W LiebalLars M Blank

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.