PMID: 22583559DOI: 10.1016/j.mehy.2012.04.031May 16, 2012Paper
How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects
Medical Hypotheses
L A Frassetto, A Sebastian
Abstract
Subjects with either type 1 or type 2 diabetes are at higher risk for having fractures, a risk not necessarily improved by better glucose control. In this article, we argue that low grade metabolic acidosis and increased oxidative stress occurring in bone disease in part as a result of complications of diabetes, reinforce each other, and together constitute a double jeopardy for the development of bone fractures in diabetic subjects.
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