How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects

Medical Hypotheses
L A Frassetto, A Sebastian

Abstract

Subjects with either type 1 or type 2 diabetes are at higher risk for having fractures, a risk not necessarily improved by better glucose control. In this article, we argue that low grade metabolic acidosis and increased oxidative stress occurring in bone disease in part as a result of complications of diabetes, reinforce each other, and together constitute a double jeopardy for the development of bone fractures in diabetic subjects.

References

Feb 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S RehncronaB K Siesjö
May 16, 1988·European Journal of Biochemistry·C FrelinM Lazdunski
Jul 1, 1986·Endocrinology·T R Arnett, D W Dempster
Jan 1, 1995·Journal of Veterinary Internal Medicine·M M ChristopherM E Peterson
Mar 11, 1996·Brain Research·A H WaterfallC A Marsden
Jan 16, 1998·Acta Physiologica Scandinavica·P A Li, B K Siesjö
Jul 13, 2000·Free Radical Biology & Medicine·F Q Schafer, G R Buettner
Jul 27, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M M Campos PastorA G García-Cervigón
Jan 11, 2002·Blood·Jonathan S HarrisonPersis Bandari
Oct 2, 2003·Nephron. Experimental Nephrology·Rana RustomMalcolm J Jackson
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A RobergsDaryl Parker
Jun 2, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C De LaetA Tenenhouse
Jun 23, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sridhar MuthusamiSrinivasan Narasimhan
Jun 28, 2006·Diabetes Care·Mohsen JanghorbaniFrank Hu
Oct 28, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Vestergaard
Feb 10, 2007·Journal of Applied Physiology·Thomas L Clanton
Feb 20, 2007·Injury·Ioannis S BenetosPanayotis N Soucacos
Apr 17, 2008·Journal of Diabetes and Its Complications·Inan AnaforogluMelek Eda Ertorer
Oct 14, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kevin K FrickDavid A Bushinsky
Feb 14, 2009·Biogerontology·S Asha DeviM V V Subramanyam
Feb 24, 2009·Bone·Yasuhiro HamadaMasafumi Fukagawa
Feb 6, 2010·Journal of Neurochemistry·Jan LewerenzPamela Maher
Jul 27, 2010·Archives of Biochemistry and Biophysics·Timothy R Arnett
Aug 20, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jian Sheng ChenPhilip N Sambrook
Dec 18, 2010·Free Radical Biology & Medicine·Justin L Rains, Sushil K Jain
Mar 5, 2011·Journal of the American Society of Nephrology : JASN·Tomokazu SoumaSadayoshi Ito

❮ Previous
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Citations

Aug 27, 2015·Journal of Agricultural and Food Chemistry·Chung-Hwan ChenChwan-Li Shen
Sep 20, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Janina M PatschThomas M Link
Mar 17, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S EpsteinUNKNOWN Scientific Committee of the First International Symposium on Diabetes and Bone
Aug 21, 2014·International Journal of Endocrinology·Nicola NapoliSol Epstein
Jan 15, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·U HeilmeierT M Link
May 8, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·U HeilmeierG Kazakia
Nov 4, 2016·Nature Reviews. Endocrinology·Nicola NapoliUNKNOWN IOF Bone and Diabetes Working Group
Jun 28, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ursula HeilmeierThomas M Link
Apr 9, 2020·International Journal of Molecular Sciences·Julia C BerkmannKatharina Schmidt-Bleek
Dec 10, 2020·The Journal of Nutrition·Jesús Francisco García-GavilánMonica Bulló
Nov 27, 2020·Acta Biomaterialia·Anna K PetersonAlix Deymier
Jun 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Piotr LondzinJoanna Folwarczna

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