PMID: 16515481Mar 7, 2006Paper

How much is enough? Modulation of dose-response curve for steroid receptor-regulated gene expression by changing concentrations of transcription factor

Current Topics in Medicinal Chemistry
S Stoney Simons

Abstract

The position of the dose-response curve for steroid-regulated gene expression determines how much variation in response will accompany the normal physiological changes in circulating steroid. Over the last several years, it has become clear that the concentration of steroid hormone required for half-maximal induction or repression by a given receptor-steroid complex, which is normally called the EC50, is not constant for all responsive genes. Thus, the position of the dose-response curve can change so that a single concentration of steroid produces very different percentages of maximal activity. This, in turn, allows for the differential expression of genes by a common steroid hormone concentration during development, differentiation, and homeostasis. Here we review the variety of factors that influence the EC50 and position of the dose-response curve for steroid hormone receptors, discuss what is known about the mechanisms, and highlight promising areas for future research.

Citations

Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Karen M OngCarson C Chow
Apr 9, 2010·BMC Cancer·Yuanzheng HeS Stoney Simons
May 17, 2008·Molecular Endocrinology·Weiwei ChenMichael J Garabedian
Jun 24, 2011·PLoS Genetics·Sean Michael CarrollJoseph W Thornton
Apr 26, 2014·Cell Research·Yuanzheng HeH Eric Xu
Jun 28, 2008·Molecular and Cellular Endocrinology·Yunguang SunS Stoney Simons
Jul 16, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Stoney Simons
May 26, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Yuli KimS Stoney Simons
Jan 1, 2014·Molecular and Cellular Endocrinology·Dong-Hee HanSehyung Cho
Jun 15, 2011·Molecular and Cellular Endocrinology·S Stoney Simons, Carson C Chow
Jul 11, 2013·Regulatory Toxicology and Pharmacology : RTP·Christopher J BorgertJohn C Matthews
Feb 3, 2016·Journal of Molecular Endocrinology·Katherine A LeehyJulie H Ostrander
Dec 24, 2019·Frontiers in Genetics·Zhihua NiDeng-Ke Niu
Mar 30, 2018·Frontiers in Endocrinology·Carson C Chow, S Stoney Simons

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