How Nanotechnology and Biomedical Engineering Are Supporting the Identification of Predictive Biomarkers in Neuro-Oncology

Medicines
Mario GanauSalvatore Chibbaro

Abstract

The field of neuro-oncology is rapidly progressing and internalizing many of the recent discoveries coming from research conducted in basic science laboratories worldwide. This systematic review aims to summarize the impact of nanotechnology and biomedical engineering in defining clinically meaningful predictive biomarkers with a potential application in the management of patients with brain tumors. Data were collected through a review of the existing English literature performed on Scopus, MEDLINE, MEDLINE in Process, EMBASE, and/or Cochrane Central Register of Controlled Trials: all available basic science and clinical papers relevant to address the above-stated research question were included and analyzed in this study. Based on the results of this systematic review we can conclude that: (1) the advances in nanotechnology and bioengineering are supporting tremendous efforts in optimizing the methods for genomic, epigenomic and proteomic profiling; (2) a successful translational approach is attempting to identify a growing number of biomarkers, some of which appear to be promising candidates in many areas of neuro-oncology; (3) the designing of Randomized Controlled Trials will be warranted to better define the prognostic val...Continue Reading

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Citations

Sep 6, 2019·Journal of Clinical Medicine·Angus LindsaySteven P Gieseg
Nov 27, 2019·Journal of Clinical Medicine·Pia S ZeinerMichael W Ronellenfitsch
Feb 23, 2020·Journal of Clinical Medicine·Ros WhelanTodd Hankinson
Jan 7, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Q LiuH Zhang
May 30, 2021·Biotechnology and Bioengineering·Sinan AkgölKevser Kuşat

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Methods Mentioned

BETA
biosensors
surgical resection
biosensor
chip
PCR
fluorescence microscopy
proteomic profiling

Software Mentioned

DIRECTOR
BEST
Biomarkers , EndpointS , and other Tools ( BEST )

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