How nonbacterial osteomyelitis could be discriminated from tuberculosis in the early stages: the simple algorithm

Clinical Rheumatology
Mikhail M KostikAlexander Yu Mushkin

Abstract

Chronic nonbacterial osteomyelitis (CNО) and tuberculous osteomyelitis (TBO) are both primarily chronic inflammatory bone diseases with similar clinical and radiological findings, but entirely different in aetiology, pathogenesis, treatment, and outcomes. Our study aimed to evaluate the clinical and laboratory features which could discriminate the CNO and TBO. The study included 124 patients-91 with CNO and 33 with TBO. All patients underwent routine blood tests: WBC, platelets, ESR, C-reactive protein, haemoglobin, and imaging. The ability of each variable to discriminate CNO from TBO was evaluated with sensitivity and specificity analysis, AUC-ROC analysis, and calculating the odds ratio. Patients with TBO had less number of bone foci (p = 0.0000001), onset age (p = 0.00001), rarely articular involvement (p = 0.01), lower haemoglobin level (p = 0.02), higher incidence of TBO in the male subjects (p = 0.002), and higher leukocyte bands (p = 0.0000001). TBO is rarely characterized by spine (p = 0.0009), foot (p = 0.01), and clavicula (p = 0.047) involvement. The diagnostic rule: criteria allowing to differentiate NBO from TBO are negative bone microbiota tests (sensitivity-100.0%, specificity-100.0%) or major discriminative cri...Continue Reading

References

Nov 22, 2005·Infectious Disease Clinics of North America·Michael Gardam, Sue Lim
Apr 1, 2009·Arthritis and Rheumatism·Annette F JanssonVolkmar Jansson
Mar 1, 2011·Acta Paediatrica·Annette F JanssonUNKNOWN ESPED Study Group
Apr 29, 2015·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sarah KhanIan Kitai
Mar 10, 2016·The Pediatric Infectious Disease Journal·Laura PöyhönenMatti Korppi
Jun 19, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Bonnie L PadwaCory M Resnick
Jul 28, 2016·Paediatrics and International Child Health·Pooja DewanShuaib Qureshi
Sep 1, 2016·Pediatric Rheumatology Online Journal·M R RoderickA V Ramanan
Nov 3, 2016·The Journal of Rheumatology·Sigrun R HofmannChristian M Hedrich
Oct 14, 2016·QJM : Monthly Journal of the Association of Physicians·S G ChongA M McLaughlin
Oct 30, 2016·Journal of Clinical and Diagnostic Research : JCDR·Aniruddha Sinha SarkarSumanta Pal
Mar 16, 2017·Infectious Disease Clinics of North America·John I HoganSandra B Nelson
Jul 4, 2017·Journal of Paediatrics and Child Health·Nawal El HoumamiPierre-Edouard Fournier
Oct 31, 2017·The Open Orthopaedics Journal·Mandeep Singh DhillonSampat Dumbre Patil
Nov 8, 2017·Nature Reviews. Microbiology·Lucy C K Bell, Mahdad Noursadeghi
Nov 8, 2017·Arthritis Care & Research·Yongdong ZhaoUNKNOWN Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis Study Group and the Childhood Arthritis and Rh
Nov 11, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Rebecca van GrootveldHerman F Wunderink
Dec 25, 2017·BMJ Case Reports·Michael Howard Baca-Atlas, Amir Homayoun Barzin
Feb 21, 2018·Nephrology·S V Padmavathi DeviV Siva Kumar
Dec 15, 2018·Pediatric Rheumatology Online Journal·Melissa OliverUNKNOWN CARRA SVARD CRMO/CNO workgroup
Jan 9, 2019·Journal of Korean Medical Science·Youn Young ChoiEun Hwa Choi
May 7, 2019·Journal of Chemotherapy·Tommaso MatucciElena Chiappini
Oct 28, 2019·Annals of Laboratory Medicine·Suhyun OhJeong Rae Yoo
Nov 30, 2019·Pediatric Clinics of North America·Robert DolitskyChristopher Collins
Jan 17, 2020·Pediatric Rheumatology Online Journal·Austin GaalMark Egbert
Jan 24, 2020·The American Journal of Tropical Medicine and Hygiene·Eric SinLuis A Marcos
Jan 25, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Alejandro Jaime-VillalongaGoran Miljkovic
Feb 27, 2020·Journal of Clinical Orthopaedics and Trauma·Anil Agarwal
Mar 5, 2020·The New England Journal of Medicine·Guy Thwaites, Payam Nahid
Mar 13, 2020·The Journal of Clinical Investigation·Gaspard KernerJacinta Bustamante
Mar 21, 2020·The Indian Journal of Tuberculosis·I ShahA Nene

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Citations

Dec 6, 2020·Current Opinion in Pediatrics·Fernando Moreno-MateoKaren Brandt Onel

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