How paraproteins can affect laboratory assays: spurious results and biological effects

Pathology
Richard I King, Christopher M Florkowski

Abstract

The presence of large amounts of monoclonal paraprotein in the serum can lead to a range of spurious laboratory results. These may result from analytical interference of the M-protein through chemical or immunological means, or from pre-analytical interference; the different modes of interference are explored in this review along with suggested methods of prevention or detection.

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Citations

May 18, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Christof SchildJean-Marc Nuoffer
Jul 1, 2014·Archives of Pathology & Laboratory Medicine·Lu SongAnthony W Butch
Jan 18, 2011·Pathology·Raashda SulaimanRousseau Gama
Nov 30, 2014·Clinical Chemistry·Joshua A Hayden, Geoffrey Baird
Feb 14, 2020·Laboratory Medicine·Milena NjegovanPetar Gaćina
Oct 23, 2019·The Journal of Applied Laboratory Medicine·Lu SongCurtis D Chin
Feb 13, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Jean-Baptiste OudartLaurent Ramont
Oct 30, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Helle Borgstrøm HagerMorten Lindberg

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