How progressive cancer endangers the heart: an intriguing and underestimated problem.

Cancer Metastasis Reviews
Simonetta AusoniGiuseppe Azzarello

Abstract

Since it came into being as a discipline, cardio-oncology has focused on the prevention and treatment of cardiotoxicity induced by antitumor chemotherapy and radiotherapy. Over time, it has been proved that even more detrimental is the direct effect generated by cancer cells that release pro-cachectic factors in the bloodstream. Secreted molecules target different organs at a distance, including the heart. Inflammatory and neuronal modulators released by the tumor bulk, either as free molecules or through exosomes, contribute to the pathogenesis of cardiac disease. Progressive cancer causes cachexia and severe cardiac muscle wasting accompanied by cardiomyocyte atrophy, tissue fibrosis, and several functional impairments up to heart failure. The molecular mechanisms responsible for such a cardiac muscle wasting have been partially elucidated in animal models, but minimally investigated in humans, although severe cardiac dysfunction exacerbates global cachexia and hampers efficient anti-cancer treatments. This review provides an overview of cancer-induced structural cardiac and functional damage, drawing on both clinical and scientific research. We start by looking at the pathophysiological mechanisms and evolving epidemiology a...Continue Reading

References

Sep 14, 1999·The American Journal of Physiology·G F TorelliF Rossi Fanelli
Jul 19, 2002·The New England Journal of Medicine·Alan S MaiselUNKNOWN Breathing Not Properly Multinational Study Investigators
Aug 3, 2002·Nature Reviews. Immunology·Clotilde ThérySebastian Amigorena
Aug 7, 2002·International Journal of Cardiology·Stefan D Anker, Rakesh Sharma
Nov 5, 2002·Nature Reviews. Cancer·Michael J Tisdale
May 21, 2003·Annals of Internal Medicine·Hyon J KwonM Miles Braun
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Jun 3, 2004·Lancet·Michael E FranksWilliam D Figg
Jul 9, 2004·International Journal of Cancer. Journal International Du Cancer·Mohamed H ZakiMohit Trikha
Dec 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Vishram KedarCam Patterson
Apr 6, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Christopher Deans, Stephen J Wigmore
Feb 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charu DograAshok Kumar
Jun 15, 2007·British Journal of Haematology·Orciuolo EnricoPetrini Mario
Jul 13, 2007·CA: a Cancer Journal for Clinicians·Robert D LobergKenneth J Pienta
Sep 22, 2007·Critical Care Medicine·Michael MenconiPer-Olof Hasselgren
Dec 7, 2007·Cell Metabolism·Cristina MammucariMarco Sandri
Jun 11, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Benjamin H L Tan, Kenneth C H Fearon
Jul 18, 2008·International Journal of Hematology·Abdullah HacihanefiogluEmel Gonullu
Aug 23, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·William J EvansStefan D Anker
Oct 7, 2008·Annual Review of Pharmacology and Toxicology·Alan L Schwartz, Aaron Ciechanover
Jan 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Monte S WillisCam Patterson
Aug 12, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Aminah JatoiCharles L Loprinzi
Nov 10, 2009·Frontiers in Neuroendocrinology·T R CastañedaM H Tschöp
Mar 30, 2010·Physiology & Behavior·Aaron J GrossbergDaniel L Marks
Jul 3, 2010·International Journal of Oncology·Min TianMartha A Belury
Aug 25, 2010·Current Opinion in Supportive and Palliative Care·Benjamin H L Tan, Kenneth C H Fearon
Dec 18, 2010·Cancer Research·Pippa F Cosper, Leslie A Leinwand
Dec 21, 2010·Life Sciences·Hui XuLoren E Wold
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
Mar 2, 2011·The American Journal of Pathology·Ashley WysongMonte S Willis
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 23, 2011·Current Problems in Cancer·Norleena P GullettThomas R Ziegler
Apr 28, 2011·European Journal of Cancer Care·E A WilkesZ H Khan

❮ Previous
Next ❯

Citations

Apr 2, 2020·International Journal of Molecular Sciences·Guilherme Wesley Peixoto da FonsecaMitja Lainscak
Nov 18, 2020·Journal of Cachexia, Sarcopenia and Muscle·Joshua R HuotAndrea Bonetto
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Simonetta Ausoni, Giuseppe Azzarello

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
ubiquitination
deubiquitination

Clinical Trials Mentioned

NCT03631199
NCT03626545
NCT01433263

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Related Papers

Journal of Cachexia, Sarcopenia and Muscle
Seyyed M R Kazemi-BajestaniVickie E Baracos
American Journal of Physiology. Heart and Circulatory Physiology
Kate T Murphy
Current Opinion in Supportive and Palliative Care
Alessia LenaMarkus S Anker
Current Opinion in Clinical Nutrition and Metabolic Care
Gerasimos S FilippatosDimitrios T Kremastinos
JPEN. Journal of Parenteral and Enteral Nutrition
Adam RahmanRavi Agarwala
© 2021 Meta ULC. All rights reserved