How protein chemists learned about the hydrophobic factor

Protein Science : a Publication of the Protein Society
C Tanford

Abstract

It is generally accepted today that the hydrophobic force is the dominant energetic factor that leads to the folding of polypeptide chains into compact globular entities. This principle was first explicitly introduced to protein chemists in 1938 by Irving Langmuir, past master in the application of hydrophobicity to other problems, and was enthusiastically endorsed by J.D. Bernal. But both proposal and endorsement came in the course of a debate about a quite different structural principle, the so-called "cyclol hypothesis" proposed by D. Wrinch, which soon proved to be theoretically and experimentally unsupportable. Being a more tangible idea, directly expressed in structural terms, the cyclol hypothesis received more attention than the hydrophobic principle and the latter never actually entered the mainstream of protein science until 1959, when it was thrust into the limelight in a lucid review by W. Kauzmann. A theoretical paper by H.S. Frank and M. Evans, not itself related to protein folding, probably played a major role in the acceptance of the hydrophobicity concept by protein chemists because it provided a crude but tangible picture of the origin of hydrophobicity per se in terms of water structure.

References

Nov 1, 1992·Protein Science : a Publication of the Protein Society·J T Edsall
Jun 1, 1966·Toxicon : Official Journal of the International Society on Toxinology·G Rosenfeld, E M Kelen
Jun 1, 1995·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·J C HagerS A Barman
Jan 1, 1993·Annual Review of Biophysics and Biomolecular Structure·G D Rose, R Wolfenden
Apr 1, 1993·Protein Science : a Publication of the Protein Society·W Kauzmann
May 1, 1952·The Journal of General Physiology·A D HERSHEY, M CHASE
Jan 9, 1954·Nature·J BELEHRADEK
Jan 1, 1954·Advances in Protein Chemistry·D F WAUGH
Jan 1, 1959·Advances in Protein Chemistry·W KAUZMANN
Apr 1, 1951·Proceedings of the National Academy of Sciences of the United States of America·L PAULINGH R BRANSON
Jul 1, 1936·Proceedings of the National Academy of Sciences of the United States of America·A E Mirsky, L Pauling
Nov 1, 1951·Proceedings of the National Academy of Sciences of the United States of America·L Pauling, R B Corey
Jan 15, 1937·Science·I LangmuirD M Wrinch
Sep 3, 1949·Nature·C F JACOBSEN, K LINDERSTRØM-LANG
Mar 31, 1925·The Journal of Experimental Medicine·E Gorter, F Grendel

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Citations

Mar 8, 2000·Cell Motility and the Cytoskeleton·H T Idriss
Jul 1, 1997·Mass Spectrometry Reviews·R L Winston, M C Fitzgerald
Mar 17, 1999·Journal of Molecular Recognition : JMR·T NeufeldG Fleminger
Aug 10, 1999·Journal of Molecular Recognition : JMR·R R Gabdoulline, R C Wade
Feb 19, 2000·Journal of Molecular Recognition : JMR·P E Smith, J J Tanner
May 27, 1999·Electrophoresis·M Quadroni, P James
Feb 17, 2001·Journal of Molecular Recognition : JMR·I V OuporovK A Thomasson
Feb 17, 2001·Journal of Molecular Recognition : JMR·A P Demchenko
Sep 2, 2000·Journal of Peptide Science : an Official Publication of the European Peptide Society·I LaczkóJ Molnár
Mar 10, 2001·Angewandte Chemie·Henry Strasdeit
Dec 20, 2002·Angewandte Chemie·Stefan Walter, Johannes Buchner
Jun 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C P PontingD J Blake
Jan 12, 2002·Biopolymers·Debnath Pal, Pinak Chakrabarti
Oct 23, 2001·Biotechnology and Bioengineering·J L McNayE J Fernandez
Aug 14, 2001·Journal of Cellular Biochemistry·S M NgaiR S Hodges
Mar 27, 2002·Journal of Computational Chemistry·Keith D BallKen A Dill
Mar 27, 2002·Journal of Computational Chemistry·Hagai Meirovitch
Nov 5, 2004·Journal of Computational Chemistry·Maria KontoyianniLaura M McClellan
Dec 18, 2001·Journal of Molecular Recognition : JMR·C GustafssonR Emig
Dec 26, 2002·Journal of Molecular Recognition : JMR·A V VeselovskyP Janssen
Sep 5, 2002·Mass Spectrometry Reviews·Igor A Kaltashov, Stephen J Eyles
Dec 12, 2002·Mass Spectrometry Reviews·Jeffrey J GormanJames J Pitt
May 6, 1998·Protein Science : a Publication of the Protein Society·A R Khan, M N James
Jul 26, 2005·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Kazuhiro IrieHajime Ohigashi
Nov 19, 2003·Archives of Biochemistry and Biophysics·Saule NaureckieneBrendan Bingham
Jun 24, 2004·Cellular Signalling·Bai LuoMatthew K Topham

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