How reggies regulate regeneration and axon growth

Cell and Tissue Research
Claudia A O Stuermer

Abstract

The microdomain-forming proteins reggie-1 and reggie-2 (alias flotillins) were found to be upregulated in axon-regenerating fish retinal ganglion cells (RGCs). They were subsequently shown to be indispensible for axon regeneration and neurite extension in fish and mammals. Our current concept proposes that reggies--often together with the cellular Prion protein (PrP)--regulate the turnover of membrane and specific membrane proteins at the growth cone, which is the prerequisite for neurite elongation and guidance.

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Citations

Jun 16, 2012·Cell and Tissue Research·H W MüllerM Bähr
May 4, 2013·Cell and Tissue Research·Petar CharalambousKlaus Unsicker
Oct 1, 2014·Communicative & Integrative Biology·Felix Dempwolff, Peter L Graumann
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Sep 17, 2020·International Journal of Molecular Sciences·Mariana Brandão PradoMarilene Hohmuth Lopes
Jul 19, 2017·The Journal of Eukaryotic Microbiology·Helmut Plattner
Jul 3, 2021·Frontiers in Psychiatry·Niels HansenCharles Timäus

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