How reliable are ADC measurements? A phantom and clinical study of cervical lymph nodes

European Radiology
Bastien MoreauHubert Beaumont

Abstract

To assess the reliability of ADC measurements in vitro and in cervical lymph nodes of healthy volunteers. We used a GE 1.5 T MRI scanner and a first ice-water phantom according to recommendations released by the Quantitative Imaging Biomarker Alliance (QIBA) for assessing ADC against reference values. We analysed the target size effect by using a second phantom made of six inserted spheres with diameters ranging from 10 to 37 mm. Thirteen healthy volunteers were also scanned to assess the inter- and intra-observer reproducibility of volumetric ADC measurements of cervical lymph nodes. On the ice-water phantom, the error in ADC measurements was less than 4.3 %. The spatial bias due to the non-linearity of gradient fields was found to be 24 % at 8 cm from the isocentre. ADC measure reliability decreased when addressing small targets due to partial volume effects (up to 12.8 %). The mean ADC value of cervical lymph nodes was 0.87.10-3 ± 0.12.10-3 mm2/s with a good intra-observer reliability. Inter-observer reproducibility featured a bias of -5.5 % due to segmentation issues. ADC is a potentially important imaging biomarker in oncology; however, variability issues preclude its broader adoption. Reliable use of ADC requires technica...Continue Reading

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Aug 19, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yuwei ZhouZhiquan Huang
Jun 5, 2020·European Journal of Radiology·Hubert BeaumontAntoine Iannessi

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