How shall we treat early triple-negative breast cancer (TNBC): from the current standard to upcoming immuno-molecular strategies.

ESMO Open
Ji Hyun ParkSung-Bae Kim

Abstract

Triple-negative breast cancer (TNBC) is a long-lasting orphan disease in terms of little therapeutic progress during the past several decades and still the standard of care remains chemotherapy. Experimental discovery of molecular signatures including the 'BRCAness' highlighted the innate heterogeneity of TNBC, generating the diversity of TNBC phenotypes. As it contributes to enhancing genomic instability, it has widened the therapeutic spectrum of TNBC. In particular, unusual sensitivity to DNA damaging agents was denoted in patients with BRCA deficiency, suggesting therapeutic benefit from platinum and poly(ADP-ribose) polymerase inhibitors. However, regardless of enriched chemosensitivity and immunogenicity, majority of patients with TNBC still suffer from dismal clinical outcomes including early relapse and metastatic spread. Therefore, efforts into more precise and personalised treatment are critical at this point. Accordingly, the advance of multiomics has revealed novel actionable targets including PI3K-Akt-mTOR and epidermal growth factor receptor signalling pathways, which might actively participate in modulating the chemosensitivity and immune system. Also, TNBC has long been considered a potential protagonist of immu...Continue Reading

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Methods Mentioned

BETA
chromosomal aberrations
COLET
xenograft
genotyping

Clinical Trials Mentioned

NCT02441933
NCT01752686
NCT00148694
NCT01630226
NCT02934828
NCT02199418
NCT00813956
NCT00861705
NCT01426880
NCT00930930

Software Mentioned

IntClust
IntClust10
GeparSixto
LOTUS
IntClust4
PARTNER
EMBRACA

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