How should we introduce high-dose chemotherapeutic strategies into the adjuvant management of high-risk breast cancer in Australasia?

The Australian and New Zealand Journal of Surgery
M BackP Yuile

Abstract

Development of bone marrow support techniques has altered the standard chemotherapeutic management of haematological malignancies, and these techniques are now being increasingly utilized in solid tumours. In breast cancer, survival benefits have resulted from conventional dose adjuvant chemotherapy, but outcomes remain poor in many women with high-risk disease. Improved response rates with high-dose chemotherapy (HDC) in metastatic disease have led to the investigation of these techniques in adjuvant therapy of high-risk localized disease. In some high-risk patient subgroups survival is extremely poor, with 5-year rates below 30%. Improved adjuvant strategies for patients in these subgroups are therefore urgently required. In Australasia, oncology departments are currently considering accrual of women with high-risk disease into the International Breast Cancer Study Group (IBCSG) 15-95 Trial investigating HDC/stem cell transplantation. The present paper reviews the available data on the efficacies and toxicities of currently available high-dose chemotherapeutic strategies; discussing methodological considerations relevant to their introduction and safe use in the adjuvant setting in Australia and New Zealand. Although response...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L E RutqvistH Johansson
Jul 5, 1992·The New England Journal of Medicine·R E CurtisR N Hoover
Nov 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M OvergaardN E Sørensen
Oct 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W R BezwodaR D Dansey
May 1, 1995·Cancer Treatment Reviews·P L TriozziD E Thornton
Feb 15, 1995·JAMA : the Journal of the American Medical Association·G BonadonnaP Valagussa
Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O UngJ Boyages
May 5, 1994·The New England Journal of Medicine·W C WoodC R Ferree
Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J CuzickH Host
Jun 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W P PetersE Shpall
Dec 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R ArriagadaS Rotstein
Jul 18, 2002·Journal of the National Cancer Institute·UNKNOWN International Breast Cancer Study Group (IBCSG)
Jan 1, 1995·Medical Journal, Armed Forces India·W P Thergaonkar, D P Achar

❮ Previous
Next ❯

Citations

Oct 23, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·M F BackT P Shakespeare
Oct 28, 2008·The British Journal of Educational Psychology·Stella MavroveliAdrian Furnham
Dec 4, 2009·Child Development Perspectives·Pamela M ColeMargaret W Sullivan
Dec 17, 2008·Developmental Disabilities Research Reviews·Doré R LaforettScott H Kollins
Jun 6, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Joan LubyEd Spitznagel
Sep 21, 2010·The British Journal of Developmental Psychology·Sherri C Widen, James A Russell
Jan 11, 2002·The American Journal on Addictions·P Owen, G A Marlatt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.