How should we think about the ribosome?

Annual Review of Biophysics
Peter B Moore

Abstract

In a few years we are likely to have structures for the ribosome in all the conformations it assumes during protein synthesis. The golden age of ribosome structure determination is thus drawing to a close, and as it does the focus in the field will shift from structure determination to understanding why the ribosome's structure changes the way it does as it performs its function. Thus in the future, kinetic and thermodynamic experiments will become increasingly important, and as they do, the field will have to start thinking about the dynamics of the ribosome far more carefully than it has in the past. The reasoning that underlies these assertions will be explained, and a more general issue explored, namely what can be said today about the modus operandi of the ribosome. What kind of a device is it?

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J A Lake
Jan 20, 1992·FEBS Letters·Y u SemenkovS Kirillov
Mar 25, 1973·Journal of Molecular Biology·F EngbaekO Maaloe
Jan 1, 1969·Cold Spring Harbor Symposia on Quantitative Biology·P C Zamecnik
Jan 1, 1969·Cold Spring Harbor Symposia on Quantitative Biology·R E MonroD Vazquez
Jan 1, 1969·Cold Spring Harbor Symposia on Quantitative Biology·M R Capecchi, H A Klein
Jan 1, 1969·Cold Spring Harbor Symposia on Quantitative Biology·T CaskeyG Milman
Aug 1, 1994·Biophysical Journal·A J HuntJ Howard
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·M V RodninaW Wintermeyer
Jul 13, 2000·Journal of Molecular Biology·A SavelsberghW Wintermeyer
May 8, 2001·Science·J M OgleV Ramakrishnan
Aug 21, 2001·Cell·G Z YusupovaH F Noller
Apr 23, 2002·Current Medicinal Chemistry·C R RodriguesE J Barreiro
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·M BierR D Astumian
Jul 3, 2002·The EMBO Journal·Mikel ValleJoachim Frank
Aug 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey L HansenThomas A Steitz
Jun 25, 2003·Molecular Cell·Andreas SavelsberghWolfgang Wintermeyer
Sep 20, 1958·Nature·A TISSIERES, J D WATSON
Jun 15, 2005·Annual Review of Biochemistry·James M Ogle, V Ramakrishnan
Nov 15, 2005·Nature·Elio A AbbondanzieriSteven M Block
Aug 31, 2006·Proceedings of the National Academy of Sciences of the United States of America·Berthold WildenWolfgang Wintermeyer
Oct 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Veysel BerkJamie H Doudna Cate
Dec 26, 2006·Molecular Cell·Shinichiro ShojiKurt Fredrick
Feb 24, 2007·Molecular Cell·James B MunroScott C Blanchard
Feb 24, 2007·Molecular Cell·Dongli PanBarry S Cooperman
Mar 21, 2007·Nature Structural & Molecular Biology·Andrey L KonevegaMarina V Rodnina

❮ Previous
Next ❯

Citations

Nov 8, 2012·Nature Nanotechnology·R Dean Astumian
Jun 12, 2013·Annual Review of Biochemistry·Rebecca M Voorhees, V Ramakrishnan
Mar 13, 2014·Annual Review of Biochemistry·Christopher J Oldfield, A Keith Dunker
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Hee-Kyung KimIgnacio Tinoco
Nov 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nelson B OlivierScott C Blanchard
Sep 19, 2014·ELife·Jonathan M StokesEric D Brown
May 6, 2015·International Journal of Molecular Sciences·Xabier Agirrezabala, Mikel Valle
Jan 26, 2016·Nature Structural & Molecular Biology·Dejiu ZhangYan Qin
Nov 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ali DashtiAbbas Ourmazd
Nov 13, 2012·Current Opinion in Structural Biology·Jin ChenJoseph D Puglisi
Aug 22, 2012·Current Opinion in Structural Biology·Joachim Frank
Jun 24, 2016·Translation·Botao Liu, Shu-Bing Qian
Mar 2, 2016·Nature Structural & Molecular Biology·Michael R WassermanScott C Blanchard
May 11, 2015·Cell·Elmar BehrmannChristian M T Spahn
Apr 14, 2015·Nature Structural & Molecular Biology·Xingqian ZhangShu-Bing Qian
Apr 1, 2014·Cell·Thomas R Cech, Joan A Steitz
Sep 23, 2014·Current Opinion in Structural Biology·Michael D PurdyMark Yeager
Mar 17, 2015·Nature Structural & Molecular Biology·Jonas NoeskeJamie H D Cate
Apr 28, 2016·Wiley Interdisciplinary Reviews. RNA·Clarence Ling, Dmitri N Ermolenko
Feb 9, 2017·Journal of Chemical Theory and Computation·Patrice KoehlMarc Delarue
Mar 24, 2016·Angewandte Chemie·Mathieu F ChellatRainer Riedl
Mar 25, 2017·Chemical Society Reviews·Cristian PezzatoR Dean Astumian
Aug 15, 2017·Nature Methods·Ahmad HosseinizadehAbbas Ourmazd
Jan 16, 2013·Quarterly Reviews of Biophysics·Shina C L KamerlinArieh Warshel
Apr 4, 2013·Nature Reviews. Microbiology·Andrew Robinson, Antoine M van Oijen
Dec 1, 2011·Annals of the New York Academy of Sciences·Leyi WangScott C Blanchard
May 7, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·R Dean AstumianArieh Warshel
Oct 1, 2020·Journal of Biomolecular NMR·Jan H OverbeckRemco Sprangers
Nov 17, 2011·The Journal of Biological Chemistry·Peter B Moore
May 19, 2018·PLoS Computational Biology·Jagannath MondalPramodh Vallurupalli
Jun 19, 2019·International Journal of Molecular Sciences·Youri Timsit, Daniel Bennequin
Jun 14, 2019·Chembiochem : a European Journal of Chemical Biology·Heng YinYuhong Wang
Mar 22, 2021·The Journal of Biological Chemistry·Peter B Moore
Apr 9, 2021·Journal of the American Chemical Society·Yuanning FengJ Fraser Stoddart
May 18, 2021·Nucleic Acids Research·Petar I PenevAnton S Petrov

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
fluorescence resonance
FRET
optical tweezers

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Biochemical Sciences
James B MunroScott C Blanchard
Proceedings of the National Academy of Sciences of the United States of America
Joachim FrankDerek J Taylor
Proceedings of the National Academy of Sciences of the United States of America
Lucas H Horan, Harry F Noller
© 2021 Meta ULC. All rights reserved