How should we use convalescent plasma therapies for the management of COVID-19?

Blood
Erica M WoodZoe K McQuilten

Abstract

Convalescent plasma (CP) from blood donors with antibodies to severe acute respiratory syndrome coronavirus 2 may benefit patients with COVID-19 by providing immediate passive immunity via transfusion or by being used to manufacture hyperimmune immunoglobulin preparations. Optimal product characteristics (including neutralizing antibody titers), transfusion volume, and administration timing remain to be determined. Preliminary COVID-19 CP safety data are encouraging, but establishing the clinical efficacy of CP requires an ongoing international collaborative effort. Preliminary results from large, high-quality randomized trials have recently started to be reported.

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Citations

Feb 2, 2021·Journal of Autoimmunity·Yeny Acosta-AmpudiaUNKNOWN CP-COVID-19 group
May 1, 2021·Journal of Clinical Medicine·Krešimir PavelićNandu Goswami
Jul 31, 2021·Infectious Diseases and Therapy·Matteo BassettiUNKNOWN Italian Society of Anti-infective Therapy (SITA) and the Italian Society of Pulmonology (SIP)
Sep 1, 2021·The Journal of Clinical Investigation·Shanna A Arnold EgloffCharles F LeMaistre
Oct 15, 2021·Transfusion·Luca ValentiDaniele Prati

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Software Mentioned

CAP
RECOVERY
PLACID
REMAP

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