How signaling promotes stem cell survival: trophoblast stem cells and Shp2

Developmental Cell
Amy Ralston, Janet Rossant

Abstract

Trophoblast stem (TS) cells require FGF4 for self-renewal and to prevent differentiation. In this issue of Developmental Cell, Yang and colleagues show that the tyrosine phosphatase Shp2 prevents apoptosis in TS cells, by activation of Erk and subsequent phosphorylation and destabilization of the pro-apoptotic protein Bim. These studies provide a novel link between FGF/Erk signaling and cell survival that may be relevant to other stem and progenitor cell niches.

References

Jan 13, 1995·Science·B FeldmanM Goldfarb
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·E ArmanP Lonai
Dec 16, 1998·Science·S TanakaJ Rossant
Mar 7, 2006·Developmental Cell·Wentian YangBenjamin G Neel

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Citations

Jul 31, 2009·Oncogene·J D PiñonA Villunger
Feb 17, 2007·BMC Developmental Biology·Stephen FrankenbergMagdalena Zernicka-Goetz
Jun 26, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Erica LoudenKelle H Moley
Jun 20, 2015·Journal of Cellular and Molecular Medicine·Jie ZhangRuifang Niu
Nov 2, 2016·Development·Paulina Anna Latos, Myriam Hemberger

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