How specific MHC class I and class II combinations affect disease resistance against infectious salmon anaemia in Atlantic salmon (Salmo salar)

Fish & Shellfish Immunology
Sissel KjøglumUnni Grimholt

Abstract

The aim was to evaluate the performance of selected individual MHC class I and class II alpha (A) alleles, and combinations of these on disease resistance against infectious salmon anaemia (ISA). The material consisting of 1966 fish from seven families, contained five MHC class I alleles and four MHC class II A alleles. Which representing given class II A and class II beta (B) haplotypes, totalling 19 MHC class I and class II A genotypes. The fish were challenged with infectious salmon anaemia virus (ISAV), the virus causing ISA. Dead fish were collected daily during the challenge experiment and the survivors were collected at termination. All fish were genotyped for MHC class I and class II A. The total mortality in the material was 85.14%. For MHC class I, UBA*0201 and UBA*0301 were significantly the most resistant alleles, while UBA*0601 for class I and DAA*0301 for class II A were the significantly most susceptible alleles. The analysis of combined MHC class I and class II A genotypes detected that fish with the genotype UBA*0201/*0301;DAA*0201/*0201 were the most resistant fish with a hazard ratio (HR) at 0.750, while the fish with the genotypes UBA*0601/*0801;DAA*0501/*0501 and UBA*0201/*0301;DAA*0301/*0501 were the most ...Continue Reading

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Citations

Oct 12, 2010·Journal of Computer-aided Molecular Design·Constanza CárdenasF Javier Luque
May 15, 2013·Fish & Shellfish Immunology·Uwe FischerTeruyuki Nakanishi
Dec 5, 2012·Yi chuan = Hereditas·Jia-Yi LiHuai-Liang Xu
Dec 15, 2012·Immunogenetics·Katerina A MoutouZissis Mamuris
Jan 23, 2016·Biology·Unni Grimholt
Feb 3, 2016·Molecular Ecology·Sarah J LehnertDaniel D Heath
Dec 17, 2014·Frontiers in Genetics·José M YáñezScott Newman
Sep 17, 2016·Journal of Fish Diseases·Q K DoanF Allal
Nov 12, 2017·Marine Biotechnology·Eitaro SawayamaMotohiro Takagi
Sep 19, 2014·Journal of Clinical Microbiology·Marina EyngorAvi Eldar
Jul 10, 2019·The Journal of Heredity·Solomon BoisonNicholas Robinson
Mar 12, 2019·Developmental and Comparative Immunology·Mohammed A El-MagdTarek M Mohamed

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